The use of the Revised Trauma Score as an entry criterion in traumatic hemorrhagic shock studies: data from the DCLHb clinical trials.

Introduction: The Revised Trauma Score (RTS) has been proposed as an entry criterion to identify patients with mid-range survival probability for traumatic hemorrhagic shock studies.

Hypothesis/problem: Determination of which of four RTS strata (1-3.99, 2-4.

Should morphine dosing be weight based for analgesia in the emergency department?

Objective: To determine if patient weight is predictive of the degree of analgesic response to morphine in opioid naïve patients in the emergency department (ED).

Design: Prospective observational study.

Setting: Academic, tertiary ED, designated as a level 1 trauma center.

Clinical results from transplanting incompatible live kidney donor/recipient pairs using kidney paired donation.

Context: First proposed 2 decades ago, live kidney paired donation (KPD) was considered a promising new approach to addressing the shortage of organs for transplantation. Ethical, administrative, and logistical barriers initially proved formidable and prevented the implementation of KPD programs in the United States.

Objective: To determine the feasibility and effectiveness of KPD for the management of patients with incompatible donors.