Publications by authors named "Amol Bhawane"
Article Synopsis
- Carpenter syndrome is a rare autosomal recessive disorder caused by RAB23 mutations, marked by features like craniofacial anomalies, heart disease, brachydactyly, and obesity.
- With an incidence of about one in a million births, diagnosing this syndrome can be difficult due to its variety of symptoms.
- This case report connects Carpenter syndrome to chronic kidney disease (CKD), highlighting the need for more research on the genetic links and clinical management of these conditions.
Article Synopsis
- - The case report highlights a 48-year-old woman with chronic kidney disease who developed pure red cell aplasia (PRCA) due to anti-erythropoietin (EPO) antibodies after receiving EPO injections for anemia.
- - Following a severe drop in her hemoglobin levels, she was treated with desidustat, a new oral medication that improved her hemoglobin significantly while being less likely to induce an immune response.
- - This case emphasizes the importance of quick diagnosis and the potential of desidustat as a safer alternative for treating anemia in patients, showcasing advancements in treatment within the context of the first reported case in India.
Article Synopsis
- Erythrocytosis, a rare side effect of SGLT2 inhibitors like dapagliflozin, is often overlooked in diabetic patients with chronic kidney disease (CKD), despite its documented occurrence.
- The report highlights two cases where erythrocytosis developed quickly in CKD patients on dapagliflozin, suggesting a need for increased vigilance from healthcare providers.
- Effective management involves regular hemoglobin monitoring and prompt discontinuation of the medication to prevent complications, advocating for routine blood evaluations in CKD patients undergoing SGLT2i treatment.
Bortezomib is a frequently administered immunosuppressive agent in kidney transplantation. A 30-year-old male kidney transplant recipient developed an atypical reaction on the left hand in terms of spider-like extensions, indicating erythematous inflammation along the superficial veins after bortezomib intravenous administration. The inflammation spontaneously resolved after three weeks with a bortezomib dose reduction.
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- Maintenance hemodialysis (MHD) patients are at higher risk for severe COVID-19, and this study evaluated the antibody response to the COVISHIELD vaccine after two doses.
- Among 50 MHD patients, 96% showed seropositivity, with those having a prior COVID-19 infection exhibiting significantly higher antibody levels.
- The COVISHIELD vaccine proved to be effective and safe, with mild adverse events reported in one-third of patients but no serious complications.
Autoimmune diseases may act as a trigger for atypical hemolytic uremic syndrome (aHUS). Triggers for aHUS may include autoimmune diseases, infections, metabolic conditions, pregnancy, and transplants. aHUS-mediated injury to various organs, especially kidneys, can be life-threatening.
View Article and Find Full Text PDFIgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition that has been recognized as a unified systemic disease that links many individual organ conditions that were previously considered to be unrelated. The pathological hallmark of the disease is an abundant IgG4-positive plasma cell infiltration in the affected tissues and fibrosis. It is a great mimicker of neoplastic, inflammatory, and infectious conditions.
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- Kidney transplants are a key treatment for end-stage renal disease, but conditions like atypical hemolytic uremic syndrome (aHUS) can complicate outcomes and increase rejection risks.
- This case study discusses a young adult with aHUS who successfully received an ABO-incompatible kidney transplant, thanks to a method of desensitization that lowered the risk of rejection.
- The patient was given triple immunosuppressive therapy, and after four months, follow-up tests showed no signs of rejection or recurrence of aHUS, proving that ABO-incompatible transplants can be done safely in such patients.
Article Synopsis
- * A study analyzed 47 patients with aHUS, finding that 5 underwent kidney transplants, with most diagnosed before the procedure; only one had a recurrence post-transplant.
- * Pre-transplant treatments like plasma exchange and rituximab showed promise in minimizing disease severity and promoting good kidney function after transplant, with no reported recurrences during follow-up.
Background: Atypical hemolytic uremic syndrome (aHUS) is a rare disorder triggered by various stressors. Most of the time, stressors may not be identified in patients with aHUS. The disease may remain quiescent without manifestation throughout life.
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- Tacrolimus is a crucial medication for kidney transplant patients, with its metabolism influenced by genetic variations in the CYP3A5 gene.
- A study analyzed 25 kidney transplant patients based on their CYP3A5 genetic polymorphism status, classifying them into three groups: non-expressers, intermediate expressers, and expressers.
- The findings revealed that non-expressers required higher tacrolimus doses, experienced more complications like urinary tract infections and diabetes, and highlighted the importance of genetic testing for tailored medication plans.
Spectrum of Biopsy-proven Native Kidney Disease in Central India.
Saudi J Kidney Dis Transpl
September 2022
Article Synopsis
- - The study, conducted in Nagpur and Sawangi, India, analyzed 347 native kidney biopsies from January 2017 to March 2020, aiming to determine the prevalence of renal disorders and compare findings with previous studies.
- - The average age of patients undergoing biopsies was 41.41 years, with males making up 58.5%; nephrotic syndrome was the primary reason for biopsy (36.3%), followed by nephritic syndrome (19.9%).
- - The most common findings included primary glomerulopathies (69%), with IgA nephropathy being the most prevalent (30.85%), along with significant cases of membranous nephropathy and focal segmental glomer
Article Synopsis
- Tuberculosis (TB) can lead to a specific kidney condition called glomerulonephritis, which has symptoms like blood in urine, protein in urine, swelling, high blood pressure, or kidney failure, making it hard to differentiate from other kidney issues.
- Membranous nephropathy (MN), a type of kidney disease, is rare in TB patients.
- A case study highlights a 30-year-old woman with TB who developed MN after starting treatment for TB, which improved after she completed her anti-TB therapy.
C3 glomerulopathy is usually seen with the presence of C3 nephritic factor, homozygous or heterozygous mutations in the regulatory complement proteins factor H, factor I, or C3. We describe the presence of heterozygous laminin β2 mutation in a patient of C3 glomerulonephritis with ocular and central nervous system involvement, the significance of which is unknown.
View Article and Find Full Text PDFDiabetic muscle infarction is underdiagnosed complication occurring in dialysis patients with advanced diabetes mellitus. Atherosclerotic vascular disease and long-standing diabetes are risk factors for this painful condition. Most common presenting symptom is localized pain in the affected limb.
View Article and Find Full Text PDFThe objective of the study was to assess clinical and histopathological profile of patients who were diagnosed as immunoglobulin A nephropathy (IgAN) on renal biopsy. Medical data were collected for this retrospective study at a single center from patients with biopsy-proven IgAN, from those biopsied between January 2017 and September 2020. A total of 347 renal biopsies were performed during the study.
View Article and Find Full Text PDFIntroduction: Hemodialysis technicians play a crucial role in infection control practices in hemodialysis units. Thus, it is important to assess the knowledge and attitude towards COVID-19 among hemodialysis technicians in this pandemic situation.
Materials And Methods: An online survey composed of 22 closed-ended questions using Google Forms was conducted in the month of April (13th to 19th) 2020.
Introduction: The coronavirus disease 2019 (COVID-19) pandemic has affected the care of patients with noncommunicable diseases, including those suffering from kidney-related ailments. Many parts of the world, including India, adopted lockdown to curb community transmission of disease. The lockdown affected transportation, access to health care facilities, and availability of medicines and consumables as well as outpatient and inpatient services.
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