Publications by authors named "Amogh Gorantla"
Article Synopsis
- Achieving ultra-long-term release of hydrophilic drugs (over six months) poses a challenge for existing long-acting injectables (LAIs), which often face issues like burst release and rapid drug diffusion due to their design.
- A new injectable platform called ISCD, created using a methacrylated ultra-low molecular weight pre-polymer (polycaprolactone), addresses these issues by minimizing burst release and controlling water exchange through a dense mesh network.
- Studies show that ISCD successfully delivers various hydrophilic drugs (including antiretrovirals and antibiotics) and enables co-delivery of multiple drugs, with the potential for improved adherence in chronic conditions while surpassing the one-month drug release standard of existing LA
The development of biomaterials for protein delivery is an emerging field that spans materials science, bioengineering, and medicine. In this review, we highlight the immense potential of protein-delivering biomaterials as therapeutic options and discuss the multifaceted challenges inherent to the field. We address current advancements and approaches in protein delivery that leverage stimuli-responsive materials, harness advanced fabrication techniques like 3D printing, and integrate nanotechnologies for greater targeting and improved stability, efficacy, and tolerability profiles.
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