Publications by authors named "Amogechukwu O Ugwu"
Article Synopsis
- This study investigates mortality trends related to psychoactive substance use disorders in the U.S. from 1999 to 2020, highlighting significant public health implications.
- Utilizing data from the CDC's WONDER database, the research analyzed records from 239,573 individuals and found an overall mortality rate of 3.55 per 100,000, with notable differences across gender, age, and ethnicity.
- Key findings indicate that males had higher mortality rates (5.32 per 100,000) compared to females (1.80 per 100,000), and the 55-64 age group had the highest risks (8.24 per 100,000) compared to younger age brackets.
Derangements of neuroimmune, neurotrophic and neurochemical homeostasis have important implications in psychosocial stress-induced psychopathologies. Whether quercetin, a neuroactive compound, protects against psychosocial stress-induced psychiatric disturbances particularly via neurochemical mechanisms remain less well elucidated. Therefore, we further investigated the putative neurochemical as well as other cellular mechanisms of quercetin on social-defeat stress (SDS) model of psychosocial impairments.
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