Physical Activity in Pre-Ambulatory Children with Cerebral Palsy: An Exploratory Validation Study to Distinguish Active vs. Sedentary Time Using Wearable Sensors.

Wearable inertial sensor technology affords opportunities to record the physical activity of young children in their natural environments. The interpretation of these data, however, requires validation. The purpose of this study was to develop and establish the criterion validity of a method of quantifying active and sedentary physical activity using an inertial sensor for pre-ambulatory children with cerebral palsy.

Rewiring cancer: 3D genome determinants of cancer hallmarks.

In modern cancer biology, Hanahan and Weinberg's classic depiction of the Hallmarks of Cancer serves as a heuristic for understanding malignant phenotypes [1]. Genetic determinants of these phenotypes promote cancer induction and progression, and these mutations drive current approaches to understanding and treating cancer. Meanwhile, for over a century, pathologists have noted that profound alterations of nuclear structure accompany transformation, integrating these changes into diagnostic classifications (Figure 1).

Bridging the gap between ecological succession of fleshy-fruited shrubs and restoration frameworks in semiarid oldfields.

Abandoned agricultural areas (i.e. oldfields) represent an opportunity for natural vegetation recovery, increasing soil carbon sequestration and lessening the impacts of climate change and desertification.

A construct validation of the perceived Negative Context of Reception Scale with Indian American youth.

Objectives: Crucial to the resettlement experiences of immigrants is the degree to which the receiving country accepts them and affords them social support and opportunities. Through the factor structure and incremental validity of scores generated by the Negative Context of Reception (NCR) Scale, in the present study, we examine Indian American youths' perception of their context of reception using a sample of youth residing in the United States.

Method: Data came from a sample of 223 Indian American youth (aged 12-17) as part of a larger convergent mixed-methods project.

Efficacy and safety of advanced hybrid closed loop systems in children with type 1 diabetes younger than 6 years.

Background: Tight glycemic control is essential for the normal growth and development of preschool children. The aim of our study was to evaluate the impact of advanced hybrid closed loop (AHCL) systems in a real-life setting in children younger than 6 years.

Methods: We conducted a two-center prospective study.

Modeling population dynamics of invasive pines to optimize their control in native grasslands of Argentina.

The spread of invasive alien species over natural environments has become one of the most serious threats to biodiversity and the functioning of ecosystems worldwide. Understanding the population attributes that allow a given species to become invasive is crucial for improving prevention and control interventions. Pampas grasslands are particularly sensitive to the invasion of exotic woody plants.

"Everything is kind of the same except my mind is with me": exploring cannabis substitution in a sample of adults in early recovery from an opioid or stimulant addiction.

Background: Recovery from addiction is frequently equated with abstinence. However, some individuals who resolve an addiction continue to use substances, including via substitution (i.e.

Can environmental factors increase oxidative responses in fish exposed to polycyclic aromatic hydrocarbons (PAHs)?

Relations among polycyclic aromatic hydrocarbons (PAHs), biomarkers of oxidative stress (lipid peroxidation, glutathione, and glutathione S-transferase activity), and the possible influence of environmental factors (temperature, pH, and salinity) were assessed in situ for specimens of Ramnogaster arcuata, a native estuarine fish. PAH levels found in the muscular tissue of R. arcuata ranged from 0.

Thyroiditis and COVID-19: focus on pediatric age. A narrative review.

Purpose: In light of the growing concern over the possible link between SARS-CoV2 infection and autoimmune diseases, we conducted a review to investigate the impact of the pandemic outbreak on thyroid diseases.

Methods: We carried out a narrative review of all pediatric cases described in the literature, mainly focusing on the possible association of COVID-19 with the incidence of autoimmune and post-infective thyroid diseases (namely Hashimoto's Thyroiditis (HT), Grave's Disease (GD) and Sub-Acute Thyroiditis (SAT)). We also felt it was necessary to provide a brief review of Non-thyroidal Illness Syndrome (NTIS) and Multisystem Inflammatory Syndrome in Children (MIS-C) because of their overlap with thyroiditis.

Examining the Role of Cultural and Family Factors in Substance Use Risk Among Indian American Youth.

Introduction: Although Indian Americans constitute the second-largest immigrant group in the United States, there is a paucity of information about Indian American youth, particularly with respect to substance use risk. We examined the relationship of social factors to permissive substance use beliefs (a proxy for substance use risk since they can lead to adulthood substance use and misuse) and family functioning.

Methods: The study used structural equation modeling to examine the prevalence of permissive substance use beliefs in a sample of Indian American youth ages 12-17 ( = 223) and examined the degree to which discrimination, bicultural identity integration, and endorsement of the model minority stereotype were associated with permissive substance use beliefs.

Tall stature and gigantism in transition age: clinical and genetic aspects-a literature review and recommendations.

Purpose: Tall stature is defined as height greater than the threshold of more than 2 standard deviations above the average population height for age, sex, and ethnicity. Many studies have described the main aspects of this condition during puberty, but an analysis of the characteristics that the physician should consider in the differential diagnosis of gigantism-tall stature secondary to a pituitary tumour-during the transition age (15-25 years) is still lacking.

Methods: A comprehensive search of English-language original articles was conducted in the MEDLINE database (December 2021-March 2022).

Meet the authors: Amy Lee, Shaoni Mukhopadhyay, and Maria Amodeo.

We talk to corresponding author Amy Lee and co-authors Shaoni Mukhopadhyay and Maria Amodeo about their scientific journey, research interests, and some behind-the-scenes details of their paper "eIF3d controls the persistent integrated stress response" (this issue of Molecular Cell).

eIF3d controls the persistent integrated stress response.

Cells respond to intrinsic and extrinsic stresses by reducing global protein synthesis and activating gene programs necessary for survival. Here, we show that the integrated stress response (ISR) is driven by the non-canonical cap-binding protein eIF3d that acts as a critical effector to control core stress response orchestrators, the translation factor eIF2α and the transcription factor ATF4. We find that during persistent stress, eIF3d activates the translation of the kinase GCN2, inducing eIF2α phosphorylation and inhibiting general protein synthesis.

Culture-negative Capnocytophaga canimorsus meningitis diagnosed by 16s ribosomal RNA polymerase chain reaction in an immunocompetent veterinarian and a review of the literature.

Capnocytophaga canimorsus is a fastidious, capnophilic and facultative anaerobic Gram-negative rod found commonly in the oral flora of dogs that may cause zoonotic infections such as cellulitis and eye infections. In immunocompromised patients, it may cause fulminant sepsis. Meningitis due to C.

Strong winds as driver of surf zooplankton abundance and composition in a temperate sandy beach.

This study explores the effect of different wind events (direction and duration) on the surf zone zooplankton community in a temperate sandy beach. Samplings were realized on the surf zone of Pehuen Co sandy beach during 17 wind events from May 17th, 2017, to July 19th, 2019. Biological samples were taken before and after the events.

Interannual changes in winter-spring zooplankton estuarine community forced by hydroclimatic variability - With special reference to bioindicator species Eurytemora americana.

Climatic variability and anthropogenic pressures impact the structure and dynamics of pelagic ecosystems and copepods are good indicators of such changes. This investigation aims to explore the interannual pattern of the mesozooplankton community, in relation to environmental variables in the Bahía Blanca Estuary during winter-spring from last two decades focusing on the dominant species Eurytemora americana. Main changes recorded include increased temperature, alteration of the nutrient balance, a decrease in chlorophyll-a, modifications in the abundance-structure of the phytoplankton assemblages, and changes in the abundance-structure of the mesozooplankton community.

RNA polymerase II transcription attenuation at the yeast DNA repair gene DEF1 is biologically significant and dependent on the Hrp1 RNA-recognition motif.

Premature transcription termination (i.e. attenuation) is a potent gene regulatory mechanism that represses mRNA synthesis.

Subacute Sclerosing Panencephalitis in Children: The Archetype of Non-Vaccination.

Subacute sclerosing panencephalitis (SSPE) is a late complication of measles virus infection that occurs in previously healthy children. This disease has no specific cure and is associated with a high degree of disability and mortality. In recent years, there has been an increase in its incidence in relation to a reduction in vaccination adherence, accentuated by the COVID-19 pandemic.

Hysteresis Modeling in Iron-Dominated Magnets Based on a Multi-Layered NARX Neural Network Approach.

A full-fledged neural network modeling, based on a (NARX) architecture, is proposed for quasi-static and dynamic hysteresis loops, one of the most challenging topics for computational magnetism. This modeling approach overcomes drawbacks in attaining better than percent-level accuracy of classical and recent approaches for accelerator magnets, that combine hybridization of standard hysteretic models and neural network architectures. By means of an incremental procedure, different Deep Neural Network Architectures are selected, fine-tuned and tested in order to predict magnetic hysteresis in the context of electromagnets.

The impact of National Containment Measures on a Pediatric Italian regional Hub for COVID-19, an observational study.

Background: Numerous studies described the epidemiological link and main clinical features of pediatric COVID-19, during the first pandemic period. Our study encompasses several different phases since the National Lockdown in Italy. The primary outcome is (I) to analyze the prevalence of positive NST (Nasopharyngeal Swab Test) among the largest Italian Pediatric cohort admitted to a single regional PED Hub for COVID-19 during an eight-month period.

Endocrinological features of a patient with 14q microdeletion and Dubowitz phenotype.

Background: Dubowitz syndrome (DS) is a complex and rare condition characterized by postnatal growth retardation, microcephaly, short stature, mild developmental delay, facial dysmorphism, skin eruption and bone marrow failure. Though approximately 200 cases have been described so far, no specific genetic analysis, laboratory tests or radiological exams are available to confirm the diagnosis which is still based on clinical and facial features. Although short stature is a major feature of the syndrome, no endocrine alterations have been reported so far and scant data are available about the efficacy and safety of GH treatment in these patients.

Effects of glyphosate on soil fungal communities: A field study.

The driving forces behind many soil processes are microorganisms and they are able to respond immediately to environmental changes. The soil microbial community impacts on many soil properties. More than one-third of the terrestrial ecosystems are semiarid.