[EPIGENETIC MECHANISMS IN MODELS OF CHRONIC PAIN - A TARGET FOR NOVEL THERAPY?].

Evidence of epigenetics' role in pain response is accumulating in recent years. Tightly regulated epigenetic alterations on DNA and histones in the sensory circuit shape the physiological response to injury. Altering those epigenetic processes hinders therapeutic potential in pain.

Multiple sclerosis is associated with psoriasis. A case-control study.

Background: MS and psoriasis are both autoimmune diseases putatively mediated mainly by T cells.

Objective: We conducted a case control study to investigate whether patients with MS have a high rate of comorbid psoriasis.

Methods: The cohort consisted of 214 consecutive MS patients and a control group of 192 consecutive patients with headache.

Ketogenic diet treatment in adults with refractory epilepsy: a prospective pilot study.

Purpose: To assess the efficacy of ketogenic diet (KD) in adults with refractory epilepsy.

Methods: Eligible subjects were 18-45 years old with at least two monthly focal seizures (with or without secondary generalization) documented by 8 weeks' follow-up. Classic form of KD treatment (90% fat) was planned for 12 weeks: daily seizure diaries were kept and measurements of the urinary ketones were recorded.

[Acupuncture as complementary medicine in patients with osteoarthritis of the knee].

The popularity of integrative medicine, mainstream medical therapies combined with complementary and alternative medicine (CAM), increased in recent years in the USA and western countries. However, evidence based data on the efficacy of integrative medicine and safety is incomplete. Until recently, research on the use of acupuncture in osteoarthritis had methodological limitations such as low sample size.

Topiramate in the treatment of refractory chronic daily headache. An open trial.

Chronic daily headache (CDH) is a debilitating disorder that becomes a treatment challenge in patients refractory to the treatment. We hereby report our experience with topiramate treatment in patients with refractory CDH. The study design was a prospective, protocol-based follow-up and retrospective analysis of headache diaries.

Psychological correlates of idiopathic intracranial hypertension.

Background: Idiopathic intracranial hypertension, also known as pseudotumor cerebri, is a relatively rare disorder of increased intracranial pressure >250 mm water, with a normal neuroimaging and normal cerebrospinal fluid content.

Objectives: To examine whether hostility, anxiety and autobiographical memory (a correlate of depression) are associated with IIH.

Methods: Using a case-control cross sectional design, 20 patients with IIH were compared with 9 healthy controls of similar age, weight and height, and 11 headache controls.