Honokiol-Loaded Methoxy Poly (Ethylene Glycol) Polycaprolactone Micelles for the Treatment of Age-Related Macular Degeneration.

Age-related macular degeneration (AMD), a multifactorial age-related retinal hypoxic disorder resulting in irreversible loss of vision, is the foremost cause of blindness in the United States. Current treatment strategies involve multiple intraocular injections of antivascular endothelial growth factor (VEGF) agents into the vitreous of eye. In addition to the challenges of drug localization and targeted delivery, the need of frequent injections into the eye raises patient compliance issues, and thus call for development of sustained drug delivery systems.

The Role of Inflammation in Breast and Prostate Cancer Metastasis to Bone.

Tumor metastasis to bone is a common event in multiple forms of malignancy. Inflammation holds essential functions in homeostasis as a defense mechanism against infections and is a strategy to repair injured tissue and to adapt to stress conditions. However, exaggerated and/or persistent (chronic) inflammation may eventually become maladaptive and evoke diseases such as autoimmunity, diabetes, inflammatory tissue damage, fibrosis, and cancer.

Nanodelivery of Resveratrol-Loaded PLGA Nanoparticles for Age-Related Macular Degeneration.

Age-related macular degeneration, precisely neovascular form, is the leading cause of vision loss and the key treatment includes intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) agents. A method to increase local concentration of drug at posterior segment of the eye and to reduce the frequency of intravitreal injections is an unmet need. Resveratrol, a naturally occurring antioxidant and anti-inflammatory polyphenol, was loaded in PLGA polymeric nanoparticles to study their sustained release property and effectiveness in reducing expression of VEGF protein in vitro.

Repeated exposure of pyriproxyfen to pregnant female mice causes developmental abnormalities in prenatal pups.

The continuous exposure to conventional pesticides leads to severe health and environmental issues especially at prenatal stage during developmental period. Herein, we aimed to investigate the anomalies due to repeated exposure of pyriproxyfen in pregnant female mice and their neonates. Twenty-four pregnant female mice were repeatedly administered with pyriproxyfen at 30, 100, 300, and 1000 mg/kg by oral gauge from gestation day (GD) 7 to gestation day 17 and six females were given distilled water in the control group.

Corrigendum to "Predicting entropy generation in flow of non-Newtonian flow due to a stretching sheet with chemically reactive species" [Comput. Methods Prog. Biol. 187 (2020) 105246].

This is the corrigendum to our recent published research article [1] in which the analysis of non-Newtonian fluid (Williamson model) is presented in the presence of entropy generation by a stretched surface. Total entropy rate is discussed via thermodynamics second law. The results are arranged for nonlinear ODE's through Rung Kutta integration technique with shooting method.

Predicting entropy generation in flow of non-Newtonian flow due to a stretching sheet with chemically reactive species.

Background: We have studied the steady Darcy Forchheimer MHD generalized non-Newtonian flow of an incompressible non-linear stretched surface in the presence chemical reactive species. Darcy Forchheimer effect and chemically reactive species are considered under entropy generation. Entropy generation analysis has been essentially applied in engineering procedure in order to improve the theoretical and mathematical evaluation problems.

An investigation on some toxic effects of pyriproxyfen in adult male mice.

Objectives: Pyriproxyfen as an insect growth regulator is widely used globally for pest management. There are reports on adverse effects of insecticides such as organ toxicity, endocrine disruptions, and teratogenicity in animals and humans. We aimed to investigate reproductive toxicity of pyriproxyfen in adult male mice.

NADPH oxidase 4 mediates the protective effects of physical activity against obesity-induced vascular dysfunction.

Aims: Physical activity is one of the most potent strategies to prevent endothelial dysfunction. Recent evidence suggests vaso-protective properties of hydrogen peroxide (H2O2) produced by main endothelial NADPH oxidase isoform 4 (Nox4) in the vasculature. Therefore, we hypothesized that Nox4 connects physical activity with vaso-protective effects.

A Commentary on Telerehabilitation Services in Pakistan: Current Trends and Future Possibilities.

A 2014 World Health Organization (WHO) study reported that almost 27 million people with disability live in Pakistan with fewer than one allied rehabilitation professional per 10,000 people. The current study sought to determine the attitudes toward telerehabilitation via a survey administered to 329 Pakistani rehabilitation professionals. Study results indicate that rehabilitation professionals in Pakistan are knowledgeable about telerehabilitation and Information and Communication Technology (ICT), and are receptive to employing telerehabilitation programs and applications.

Teaching strategies and academic performances of undergraduates in quaid-I-azam medical college, bahawalpur.

Objective: to assess the outcomes and competencies of medical undergraduates regarding their learning abilities after introducing Clinical Presentation Curriculum (CPC) instead of Traditional Curriculum in Quaid-i-Azam Medical College, Bahawalpur.

Design: a cross-sectional comparative study.

Place And Duration Of Study: 3rd and 4th year MBBS class during session 2004-2005 at Quaid-i-Azam Medical College (QMC), Bahawalpur.

Estrogen replacement therapy for depression in perimenopausal women.

Objective: To determine the effect of a four-week course of oral estrogen therapy on depression in aging women.

Design: Quasi experimental.

Place And Duration Of Study: The OPD, Bahawal Victoria Hospital, Bahawalpur, from September 2000 to January 2004.

Effect of pregnancy on diabetic nephropathy and retinopathy.

Objective: To determine whether pregnancy worsens renal function in women with diabetic nephropathy and the effect of pregnancy on diabetic retinopathy.

Design: Cross-sectional analytical study.

Place And Duration Of Study: The study was conducted in OPD, Bahawal Victoria Hospital, Bahawalpur from September 1997 to June 2003.