Publications by authors named "Amna Makawi"
Article Synopsis
- The study focuses on bone marrow kinase (BMX), also known as endothelial tyrosine kinase (Etk), highlighting its importance in cancer-related processes such as cell proliferation, survival, and immune activation, while pointing out a lack of direct studies linking BMX to various cancers.
- Using databases like TIMER, GEPIA, and UALCAN, the research analyzes BMX expression across multiple cancers and finds it significantly downregulated in breast, colon, and lung cancers, suggesting it could be a useful diagnostic biomarker.
- The study also investigates the relationship between BMX expression and immune cell infiltration, revealing that higher BMX levels are linked with increased presence of immune cells, which may have implications for immunotherapy
Glioblastoma multiforme (GBM), a highly aggressive tumor of the central nervous system, is the most common malignant brain tumor and poses a significant risk to life. GBM patients have a low survival rate owing to their aggressive nature, poor prognosis, genomic variations among patients, and histopathological differences. In this study, we used several bioinformatics platforms, namely Tumor Immune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis (GEPIA), University of Alabama at Birmingham Cancer Data Analysis Portal (UALCAN) databases, Kaplan-Meier plotter, and cBioPortal, to conduct a comprehensive analysis to highlight the expression of epithelial growth factor receptor (EGFR) in patients with GBM.
View Article and Find Full Text PDFArticle Synopsis
- - Peritoneal dialysis (PD) can lead to peritonitis, often caused by gram-positive bacteria, but gram-negative organisms from the nasal and oropharyngeal area can also be responsible for this condition.
- - A case study is presented about a 29-year-old man on automated PD for 6 years who developed peritonitis, highlighting the potential for misdiagnosis of culture-negative cases.
- - Factors like poor nutrition and chronic kidney disease are linked to increased risk for peritonitis, but with proper antibiotic treatment, most patients can recover, although some might need to switch to hemodialysis.
Introduction: Peritoneal dialysis (PD) can result in peritonitis, which frequently causes severe and near-fatal clinical implications if left untreated. Usually, Gram-positive bacteria are the most common organisms involved. Uncommonly recognized as the cause of peritonitis in PD patients, Neisseria Elongata is a gram-negative nasal and oropharyngeal normal flora organism.
View Article and Find Full Text PDF