Publications by authors named "Ammar Miri"
Aims: To develop a technique using amniotic membrane (AM) to prevent admixture of conjunctival epithelial cells and limbal explant-derived corneal epithelial cells in patients undergoing limbal stem cell transplantation. To compare this technique with the current method of 'sequential sector conjunctival epitheliectomy' (SSCE).
Methods: 26 patients with total limbal stem cell deficiency who underwent ocular surface reconstruction with limbal stem cells transplantation were retrospectively studied.
To report the clinical presentation, progress and management of atypical acute hydrops. A retrospective case study of three patients with keratoconus, two of whom had previously undergone penetrating keratoplasty. The patients underwent full ophthalmological examination and digital slit-lamp imaging of the cornea throughout the course of the condition.
View Article and Find Full Text PDFPurpose: To analyse the efficacy of paired arcuate incisions and compression sutures technique in the management of post penetrating keratoplasty (PK) astigmatism.
Methods: A paired arcuate incision with compression sutures procedure was used to treat 26 eyes with post-PK astigmatism ranging from 6.00 to 16.
Purpose: To correlate in vivo confocal microscopy and impression cytology features of the corneal surface epithelia in patients with clinical features of partial or total limbal stem cell deficiency and to examine the limbal morphology.
Design: Prospective case-control observational study.
Methods: Twenty eyes of 17 consecutive patients (mean age 53.
Profile of sight-threatening infectious keratitis: a prospective study.
Acta Ophthalmol
November 2013
Purpose: To prospectively study patients presenting with sight-threatening corneal ulcers with a view to identify the predisposing factors, causative organisms, clinical signs and treatment outcomes.
Methods: Prospectively, over 3-year period, all cases with serious infective keratitis presenting to Queens Medical Hospital in Nottingham, UK, were recruited. Detailed information on the aetiology, culture results, signs & symptoms, the treatment given and the patient's response was collected and statistically analysed.
Aim: To evaluate the effect of gravity on corneal epithelial cell migration in vitro.
Methods: Fourteen donor peripheral corneoscleral rims were used. Twenty explants were chosen of which 10 were placed vertically and 10 were placed horizontally during culture.
Aim: To describe in vivo confocal microscopy (IVCM) features of the limbus in normal eyes as related to the palisades of Vogt's.
Methods: 46 eyes of 29 consecutive volunteers were recruited in this observational study. A detailed examination by IVCM was performed in addition to a routine slit-lamp biomicroscopy.
Aim: To describe in vivo confocal microscopy (IVCM) findings in patients with limbal stem cell deficiency (LSCD).
Methods: 23 eyes of 17 consecutive patients suffering from LSCD were included in this study. A detailed examination by IVCM was performed in addition to a routine slit-lamp biomicroscopy.
Purpose: To examine by histopathology the degree of nerve regeneration in human corneal grafts and to determine the anatomic organization and morphology of the regenerated nerves.
Design: Experimental laboratory investigation.
Methods: Twelve corneal grafts from 12 patients (7 men and 5 women) aged 34-93 (mean, 66.
Objective: To study the long-term changes at donor sites and safety implications for donor eyes used for harvesting tissue for autologous and living-related donor limbal transplants.
Design: Retrospective, observational, consecutive case series.
Participants: We examined 50 donor sites of limbal tissue belonging to 25 healthy eyes (23 human subjects).
Aims: To evaluate the distribution, morphometry and the postmortem changes of the central and peripheral human corneal nerves by exvivo laser-scanning confocal microscopy (EVCM).
Methods: 24 eyes from 14 cadavers were retrieved at different time intervals after death and examined by EVCM. Five regions were examined in each eye: central, superior, inferior, temporal and nasal.
Conjunctivalization of the cornea is the hallmark of limbal stem cell deficiency (LSCD). This is often associated with persistent corneal epithelial defects and a fibrovascular pannus. LSCD can be unilateral or bilateral and partial or total.
View Article and Find Full Text PDFObjective: To evaluate the long-term results of limbal stem cell transplantation (LSCT) in patients with ocular surface (OS) disease.
Design: Retrospective consecutive cohort study.
Participants: Case records of 27 eyes of 26 patients (19 males and 7 females) who presented with unilateral or bilateral total limbal stem cell deficiency and treated at the Department of Ophthalmology were examined.
Aims: Myopic fundal changes have been studied in great detail, clinically and pathologically. To our knowledge correlation between these changes and the axis of astigmatism has not been studied before. This study was conducted to assess the correlation, if any, between the pattern of myopic fundal changes and the axis of astigmatism.
View Article and Find Full Text PDFObjective: To study and characterize the epithelial cells in patients with a central "island" of normal epithelial cells surrounded with 360 degrees of clinically apparent limbal stem cell (SC) deficiency with conjunctivalization of the limbus and peripheral cornea.
Design: Observational, prospective, consecutive case series.
Participants: Five human subjects (8 eyes) who presented with total limbal SC deficiency in 1 or both eyes with a central area of normal corneal epithelial cells.