Tenecteplase or Alteplase: What Is the Thrombolytic Agent of the Future?

Purpose Of Review: Alteplase has been the thrombolytic of choice for acute ischaemic stroke for more than two decades. A thrombolytic which is easier to administer and with improved or comparable safety and efficacy is desirable. Tenecteplase has emerged as a potential successor, and its off-license use in acute ischaemic stroke has increased in recent years.

Stimulating effect of hydrostatic pressure on ultrasonic sewage sludge treatment for COD solubilization and methane production.

The performance of ultrasonic treatment was assessed under different hydrostatic pressures for two different waste activated sludges. The impact of pressurized sonication was evaluated based on the degree of disintegration (DD) and the specific methane yield (SMY). An enhancement of DD was observed at an intermediate pressure level (max.

Normobaric Oxygen Therapy in Acute Stroke: A Systematic Review and Meta-Analysis.

Purpose: Normobaric oxygen (NBO) is potentially a readily accessible neuroprotective therapy. We undertook a systematic review to assess NBO in acute stroke.

Methods: MEDLINE, EMBASE, and CENTRAL databases were searched to December 2020.

Managing epilepsy in Ramadan: Guidance for healthcare providers and patients.

Ramadan is a regularly recurring period of fasting that takes place in the ninth month of the Islamic calendar. For this period, adult Muslims refrain from eating and drinking between dawn and sunset. The variation in summer daylight hours means that at temperate latitudes, fasting can last up to 20 h.

The management of patients with aortic regurgitation and severe left ventricular dysfunction: a systematic review.

A systematic search of Medline, EMBASE and CINAHL electronic databases was performed. Original research articles reporting all-cause mortality following surgery in patients with aortic regurgitation and severe left ventricular systolic dysfunction (LVSD) were identified. Nine of the 10 eligible studies were observational, single-center, retrospective analyses.