Gastrointestinal, Respiratory, and Olfactory Neurotropism of Sars-Cov2 as a Possible Trigger of Parkinson's Disease: Is a Multi-Hit Multi-Step Process on the Cards.

Since the first emergence of COVID-19 on the global stage, there has been a wealth of evidence to suggest that SARS-Cov2 is not merely a pulmonary pathogen. This virus is unique in its ability to disrupt cellular pathways related to protein homeostasis, mitochondrial function, stress response, and aging. Such effects raise concerns about the long-term fate of survivors of COVID-19 infection, particularly regarding neurodegenerative diseases.

Parakinesia Brachialis Oscitans - a Rare Post-Stroke Phenomenon.

Background: Abnormal involuntary movement of paralyzed upper limb during yawning is a rare phenomenon termed as parakinesia brachialis oscitans.

Case Report: We describe a 59-year-old gentleman with abnormal involuntary movement of paralyzed right upper limb during yawning 2 weeks following ischemic stroke of left middle cerebral artery territory.

Discussion: This is a rare post-stroke phenomenon and its pathophysiological mechanism is poorly understood but this entity highlights possible preserved extrapyramidal pathway which might help in rehabilitating stroke survivors.

A video-based discussion of movement disorders in paediatric anti NMDAR encephalitis: A case series from Eastern India.

Purpose: The spectrum of movement disorders associated with anti N-Methyl-d-Aspartate-Receptor (NMDAR) encephalitis is myriad, particularly in children, possibilities of which were investigated from two tertiary care centres.

Methods: A retrospective study was conducted in two tertiary referral centres in Eastern India, analysing data of 8 paediatric patients diagnosed as anti NMDAR encephalitis, presenting with one or more movement disorders (MDs).

Results: All the patients were of Bengali ethnicity with a median age of 9 years (3-16 years) and with female predilection (62.

2D perovskite-based high spatial resolution X-ray detectors.

X-ray radiography is the most widely used imaging technique with applications encompassing medical and industrial imaging, homeland security, and materials research. Although a significant amount of research and development has gone into improving the spatial resolution of the current state-of-the-art indirect X-ray detectors, it is still limited by the detector thickness and microcolumnar structure quality. This paper demonstrates high spatial resolution X-ray imaging with solution-processable two-dimensional hybrid perovskite single-crystal scintillators grown inside microcapillary channels as small as 20 µm.

Recurrent ataxia and dysarthria in myelin oligodendrocyte glycoprotein antibody-associated disorder.

The spectrum of central nervous system demyelinating disorders is vast and heterogeneous and, often, with overlapping clinical presentations. Misdiagnosis might occur in some cases with serious therapeutic repercussions. However, introduction of several new biomarkers such as aquaporin-4 IgG and myelin oligodendrocyte glycoprotein IgG has made distinction between diseases such as multiple sclerosis and myelin oligodendrocyte glycoprotein antibody-associated disorder easier.

Not the Stereotypical Wilson Disease: A Case Report.

Background: Wilson disease (WD), a potentially treatable genetic disorder with perturbations in copper metabolism, presents with hepatic and neuropsychiatric manifestations. Both hyper and hypokinetic movements predominate the latter spectrum. Motor stereotypies, however, are exceedingly rare.

Correlation of ATP7B gene mutations with clinical phenotype and radiological features in Indian Wilson disease patients.

Introduction: Wilson disease (WD) is characterized by a wide variety of clinical manifestations. Our study aimed to correlate genotype with clinical and radiological features in Indian WD patients.

Methods: We conducted a descriptive observational study in a tertiary care neurology referral center of eastern India over a period of 2 years.

Anti-MOG antibody associated long segment myelitis presenting as anterior cord syndrome.

A patient having clinical features reminiscent of anterior cord syndrome (ACS) was found to have long segment myelitis on MRI. Investigations revealed serum anti-myelin oligodendrocyte glycoprotein (MOG) antibody positivity. He was treated with pulse methylprednisolone followed by immunosuppressant therapy with mycophenolate mofetil, which led to clinical recovery.

Adult-onset Kawasaki disease: A great masquerader.

Kawasaki disease is a necrotising small-to-medium vessel vasculitis affecting children between age groups of 6 months and 5 years. Following the first description in Japanese infants, it has been recognised as the single most common cause of non-infectious vasculitis in children worldwide. Presentation in adult age groups, although described, is rare.