Publications by authors named "Amith Saligrama"
Front Neurosci
October 2023
Article Synopsis
- Mutations in autism spectrum disorder (ASD) risk genes affect neural network dynamics, leading to abnormal behaviors.
- Researchers studied the hippocampal networks in transgenic mice lacking an ASD-risk gene, identifying significant learning and memory deficits tied to these mutations.
- Analysis revealed that while individual neuron excitability remained unchanged, the CA1 network in knockout mice was overly synchronized during movement, disrupting normal spatial memory functions and contributing to ASD-like behaviors.
