Publications by authors named "Amit Tuteja"
Article Synopsis
- The study focused on distinguishing Crohn's disease (CD) from intestinal tuberculosis (ITB) through gene expression analysis in colonic biopsies.
- It involved examining samples from 33 subjects to identify upregulated and downregulated genes, highlighting significant pathways associated with each condition.
- Findings indicated that FOXP3 mRNA levels in colonic mucosa could serve as a potential biomarker for differentiating between CD and ITB, with related upregulation of the complement activation pathway in ITB cases.
Unlabelled: Accurate identification and characterization of infectious agent and its subtype is essential for efficient treatment of infectious diseases on a target population of patients. Comparative biology of microbial populations in vitro and in vivo can identify signatures that may be used to develop and improve diagnostic procedures. Here we report Genomic Signature Identification Tool (GSIT) a web based tool for identification and validation of genomic signatures in a group of similar DNA sequences of microorganisms.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to explore genomic mutations in circulating Hepatitis B virus (HBV) strains in India and their impact on HBV-related diseases.
- A total of 222 HBsAg positive patients were examined, revealing HBV genotype D in 55% and genotype A in 30% of samples, with many patients showing spontaneous drug resistance mutations.
- The findings highlighted that the Core region of the virus was the most conserved, while specific mutations in the X gene were linked to a higher risk of hepatocellular carcinoma (HCC) and raised concerns about antiviral resistance.
Objective: Microarray studies have provided insight into the pathogenesis of systemic JIA and have opened new avenues for therapy. Data on the pathogenesis of the enthesitis-related arthritis (ERA) category of JIA are limited, thus we studied the expression profile of ERA patients' peripheral blood and SF mononuclear cells (PBMCs and SFMCs, respectively). PBMCs from healthy subjects were used as controls.
View Article and Find Full Text PDF