Publications by authors named "Amit Segev"
Coronary artery disease (CAD) affects over 200 million individuals globally, accounting for approximately 9 million deaths annually. Patients living with diabetes mellitus exhibit an up to fourfold increased risk of developing CAD compared to individuals without diabetes. Furthermore, CAD is responsible for 40 to 80 percent of the observed mortality rates among patients with type 2 diabetes.
View Article and Find Full Text PDFTranscatheter aortic valve replacement (TAVR) is indicated for severe aortic stenosis patients with a prohibitive surgical risk. However, its use has been expanding in recent years to include intermediate- and low-risk patients. Thus, registry data describing changes in patient characteristics and outcomes are needed.
View Article and Find Full Text PDFA decade of follow-up: atrial fibrillation, pulmonary pressure, and the progression of tricuspid regurgitation.
Eur Heart J Qual Care Clin Outcomes
August 2024
Background And Aims: Long-term data on atrial fibrillation (AF) impact on tricuspid regurgitation (TR) progression and its relation to pulmonary pressure are scant. We investigated this association in a study spanning over a decade.
Methods: Adults with echocardiographic evaluation before 2014, free of significant TR, were included.
Article Synopsis
- - The study compared outcomes for patients undergoing transcatheter aortic valve replacement (TAVR) who were admitted directly to a cardiology department versus those sent to a cardiac intensive care unit (CICU), focusing on the 2017-2018 cohort vs a previous CICU cohort.
- - It found that patients admitted to the cardiology department had shorter hospital stays (median 2 days) without increased risk of complications or rehospitalizations, as in-hospital mortality rates were zero for both groups.
- - The conclusion suggests that for stable patients after an uncomplicated TAVR procedure, direct admission to the cardiology department is a safer and more cost-effective option than CICU admission.
Background: The ACURATE neo2 transcatheter aortic valve was developed to improve paravalvular leak (PVL) rates while maintaining low rates of conduction disturbances and permanent pacemaker implantation (PPMI) seen with its predecessor. We aimed to compare conduction disturbances rates of transcatheter aortic valve replacement (TAVR) using ACURATE Neo2 with other commonly used valves.
Methods: A retrospective analysis of the Israeli TAVR registry between the years 2014-2023 was performed to compare conduction disturbances and PVL rates, and procedural outcomes, among patients treated with ACURATE neo2, Edwards Sapien 3 (S3), and Evolut PRO valves.
Purpose: To evaluate the association of cardiorespiratory fitness with elevated intraocular pressure (IOP) in healthy adults.
Methods: In this cross-sectional study, we evaluated 17,990 asymptomatic self-referred adults free of diabetes or cardiovascular disease who were screened in a preventive healthcare setting. All subjects underwent measurement of IOP and completed a maximal exercise stress test according to the Bruce protocol.
Continued circulation of severe acute respiratory syndrome coronavirus 2 has driven the selection of variants with improved ability to escape preexisting vaccine-induced responses, posing a persistent threat to heart transplant recipients (HTRs). The immunogenicity and safety of the updated XBB.1.
View Article and Find Full Text PDFUtilizing Human-Induced Pluripotent Stem Cells to Study Cardiac Electroporation Pulsed-Field Ablation.
Circ Arrhythm Electrophysiol
March 2024
Article Synopsis
- Electroporation is a nonthermal method for treating cardiac arrhythmias, and this study aimed to create a functional in vitro model using human-induced pluripotent stem cells (hiPSCs) to explore its underlying mechanisms.
- Different pulsed-field ablation (PFA) protocols were tested on hiPSC-derived cardiac cells, revealing that PFA can create conduction block areas and demonstrated both reversible and irreversible electroporation effects.
- Findings indicated that high-frequency PFA was less effective than standard methods and that factors like pulse number and extracellular calcium levels influenced lesion size, with potential applications in controlling arrhythmic activity.
Background: The ratio between early mitral flow wave to early diastolic mitral annulus velocity (E/e' ratio) varies according to age and sex and is associated with mortality in heart failure. We sought to describe the association between E/e' and mortality in patients with no apparent structural or functional cardiac abnormality and explore possible modifiers of this association.
Methods: A retrospective study of 104,315 patients who underwent echocardiographic evaluation during 2009-2021 in the largest tertiary center in Israel.
Echocardiography vs hemodynamic assessment of diastolic dysfunction.
J Invasive Cardiol
January 2024
Objectives: Ostial CTOs can be challenging to revascularize. We aim to describe the outcomes of ostial chronic total occlusion (CTO) percutaneous coronary intervention (PCI).
Methods: We examined the clinical and angiographic characteristics and procedural outcomes of 8788 CTO PCIs performed at 35 US and non-US centers between 2012 and 2022.
Article Synopsis
- * A study involving 315 patients found that after 1 year, only 4.9% experienced serious events like cardiac death or stent thrombosis, which was better than the pre-set safety target.
- * The results indicate that a 1-month DAPT is sufficient for patients with stable angina, and some acute coronary syndrome patients had DAPT extended to 3 months, with very low rates of complications.
Article Synopsis
- The ridaforolimus-eluting stent (RES) system, known as EluNIR, uses a unique cobalt alloy and polymer to treat small coronary artery disease with a diameter of 2.25 mm.
- The study assessed safety and effectiveness through a clinical trial involving 81 patients, with follow-ups at 30 days, 6 months, and 1 year, focusing on achieving low residual stenosis without major adverse events.
- Results indicated a 98.8% success rate, low rates of complications (1.2% at 30 days and 2.5% at 1 year), and highlighted the EluNIR stent as a valuable option for treating this challenging type of coronary artery issue.*
Background: New vascular closure devices (VCD) are being introduced for achieving hemostasis after transcatheter aortic valve implantation (TAVI). However, no safety or efficacy data have been published compared to other contemporary VCD.
Aim: To compare the safety and efficacy of suture-based Perclose Prostyle as compared to plug-based MANTA device.
Background: The association between mildly impaired renal function with all-site and site-specific cancer risk is not established. We aim to explore this association among apparently healthy adults.
Methods: We followed 25,073 men and women, aged 40-79 years, free of cancer or cardiovascular disease at baseline who were screened annually in preventive healthcare settings.
Background: The ridaforolimus-eluting stent (RES) system is a novel cobalt alloy-based coronary stent with a durable elastomeric polymer eluting ridaforolimus. The aim of this trial was to assess the performance of a 38 mm RES in long coronary lesions.
Methods: A prospective, multicenter, single-arm, open-label clinical trial.
Background: In the face of the global pandemic that the coronavirus disease 2019 (COVID-19) has created, readily available prognostic markers may be of great use.
Objective: To evaluate the association between serum magnesium (sMg) levels on admission and clinical outcomes in hospitalized COVID-19 patients.
Methods: We retrospectively analyzed all patients admitted to a single tertiary center with a primary de novo diagnosis of COVID-19.
Background: The association between mildly decreased renal function and cardiovascular (CV) outcomes in cancer patients remains unestablished.
Aims: We sought to explore this association in asymptomatic self-referred healthy adults.
Method: We followed 25, 274 adults, aged 40-79 years, who were screened in preventive healthcare settings.
In 2022, the antigenically divergent SARS-CoV-2 omicron variants (BA.1, BA.2, BA.
View Article and Find Full Text PDFBackground: Chronic coronary syndrome (CCS) is common among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI). Current guidelines recommend performance of percutaneous coronary intervention (PCI) of any > 70% proximal coronary lesions prior to TAVI.
Aims: To evaluate the outcomes of two diagnostic approaches for CCS clearance pre-TAVI and to determine the reduction in the need of invasive angiography (IA).
Aims: Most patients with significant (defined as ≥ moderate) tricuspid regurgitation (TR) are treated conservatively. Individual mortality rates are markedly variable. We developed a risk score based on comprehensive clinical and echocardiographic evaluation, predicting mortality on an individual patient level.
View Article and Find Full Text PDFAims: This study evaluated the impact of serum uric acid (sUA) on the accuracy of pooled cohort equations (PCE) model, Systematic COronary Risk Evaluation 2 (SCORE2), and SCORE2-older persons.
Methods And Results: We evaluated 19 769 asymptomatic self-referred adults aged 40-79 years free of cardiovascular disease and diabetes who were screened annually in a preventive healthcare setting. sUA levels were expressed as a continuous as well as a dichotomous variable (upper sex-specific tertiles defined as high sUA).
Article Synopsis
- A nationwide study in Israel investigated the impact of the COVID-19 pandemic on admissions and outcomes for patients with non-ST-segment myocardial infarction (NSTEMI) over an 8-week period.
- Results showed that 56% of NSTEMI patients were admitted during the pandemic compared to 44% in the same period two years prior, with no significant differences in demographics between the two groups.
- Despite a longer time from symptom onset to hospital admission during the pandemic, in-hospital mortality rates and 30-day mortality rates were similar across both time periods, indicating that care quality for NSTEMI may not have been adversely affected.