Publications by authors named "Amit Saha"

We have developed a novel protocol for carbonylative homocoupling of arylboronic acids using dithiocarbamate esters as the carbonyl alternative. A series of arylboronic acids underwent smooth reaction with dithiocarbamate ester (MeNCSMe) in the presence of Pd(PPh)Cl catalyst, Cu(OAc)·HO additive, and NaCO in DCE solvent, producing the biaryl ketones efficiently. The mechanism has been studied with the help of several control experiments that reveal the probability of thioamide intermediacy.

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Overnight inpatient monitoring is common following balloon pulmonary angioplasty (BPA) for chronic thromboembolic pulmonary hypertension (CTEPH). We describe our institutional experience in same-day discharge (SDD) after BPA. Across 78 BPA sessions, there were only 2 (2.

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This study has been carried out using a novel mathematical model on the dynamics of tuberculosis (TB) transmission considering vaccination, endogenous re-activation of the dormant infection, and exogenous re-infection. We can comprehend the behavior of TB under the influence of vaccination from this article. We compute the basic reproduction number ( ) as well as the vaccination reproduction number ( ) using the next-generation matrix (NGM) approach.

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Background: Thoracic surgery and one-lung ventilation in young children carry significant risks. Approaches to one-lung ventilation in young children include endobronchial intubation (mainstem intubation) and use of a bronchial blocker. We hypothesized that endobronchial intubation is associated with a greater prevalence of airway complications compared to use of a bronchial blocker.

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Purpose Of Review: To examine the evolving multifaceted nature of cardiogenic shock (CS) in the context of non-cardiac biomarkers that may improve CS management and risk stratification.

Recent Findings: There are increasing data highlighting the role of lactate, glucose, and other markers of inflammation and end-organ dysfunction in CS. These biomarkers provide a more comprehensive understanding of the concurrent hemo-metabolic and cellular disturbances observed in CS and offer insights beyond standard structural and functional cardiac assessments.

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Article Synopsis
  • A national program integrated molecular point-of-care (POC) testing for chlamydia, gonorrhoea, and trichomonas in 49 primary care clinics in Australia to improve diagnostic access and treatment speed for First Nations peoples.
  • Between 2016 and 2022, the program showed a significant increase in monthly testing, and treated a higher percentage of patients within two to seven days compared to previous practices, resulting in thousands of infectious days averted.
  • The evaluation revealed high test concordance rates and low failure rates, indicating that the POC testing was effective and of high quality, contributing to both individual health benefits and potentially reducing disease transmission in First Nations communities.
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  • A study investigated the prevalence of vestibular disorders in patients with COVID-19 compared to those without the virus using data from the National COVID Cohort Collaborative database.
  • Results showed that individuals with COVID-19 were significantly more likely to experience vestibular disorders, with the highest risk associated with the omicron 23A variant (OR of 8.80).
  • The findings underscore the need for further research on the long-term effects of vestibular disorders in COVID-19 patients and implications for patient counseling.
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Background: The objective of this study was to evaluate a modern combined video laryngoscopy and flexible fiberoptic bronchoscope approach to placement of a double lumen endobronchial tube and further characterize potential strengths and weaknesses of this approach.

Methods: Retrospective chart review was conducted at our single institution, academic medical center, tertiary-care hospital. Patients aged 18 years of age or older were evaluated who underwent thoracic surgery and one-lung ventilation with placement of a double lumen endobronchial tube using a novel combined video laryngoscopy and flexible fiberoptic bronchoscope approach.

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  • Cardiogenic shock after acute myocardial infarction remains highly lethal, prompting researchers to analyze data from 16,337 cases across 440 centers to identify characteristics linked to lower mortality.
  • The study found that centers with lower risk-adjusted in-hospital mortality rates typically had patients with fewer co-morbidities, performed more revascularizations, and showed better adherence to clinical processes.
  • Despite the presence of some beneficial factors, not all low-mortality centers demonstrated these characteristics, indicating the complexity of treating cardiogenic shock and the challenges in evaluating outcomes in such cases.
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Terminal alkynes undergo a CO-free aminocarbonylation reaction mediated by thiuram disulfides. Thiuram disulfide acts as the source of the carbamoyl group in the amidation of terminal alkynes in the presence of copper-based reagent and catalyst. A series of alkynyl amides has been prepared with several structural variations following the current one-pot two-step protocol.

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Background: Vaccine-preventable infections are generally well controlled in Australia. However, gaps in immunity can lead to outbreaks and are important to identify. Young adults are a highly mobile population and a potential source of imported infections.

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Study Objectives: The association of in-hospital medical emergency team activation (META) among patients with atrial fibrillation (AF) at risk for obstructive sleep apnea (OSA) is unclear. This study evaluates the performance of the DOISNORE50 sleep questionnaire as an OSA screener for patients with AF and determines the prevalence of META among perioperative patients with underlying AF who have a diagnosis or are at risk for OSA.

Methods: A prospective perioperative cohort of 2,926 patients with the diagnosis of AF was assessed for DOISNORE50 questionnaire screening.

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Background: Continuous and wireless vital sign monitoring is superior to intermittent monitoring in detecting vital sign abnormalities; however, the impact on clinical outcomes has not been established.

Methods: We performed a propensity-matched analysis of data describing patients admitted to general surgical wards between January 2018 and December 2019 at a single, tertiary medical centre in the USA. The primary outcome was a composite of in-hospital mortality or ICU transfer during hospitalisation.

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Objectives: To evaluate for associations between a child's neighborhood, as categorized by Child Opportunity Index (COI 2.0), and 1) PICU mortality, 2) severity of illness at PICU admission, and 3) PICU length of stay (LOS).

Design: Retrospective cohort study.

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Article Synopsis
  • - Extracellular vesicles (EVs) from plasma and urine show promise as a liquid biopsy for analyzing the renin-angiotensin system (RAS) activity in patients with primary hypertension.
  • - The study found that urinary EVs from patients with uncontrolled hypertension had larger sizes and significantly higher chymase activity, a key enzyme in the RAS, compared to controlled patients.
  • - The presence of bioactive RAS enzymes, particularly chymase, in EVs indicates a potential new mechanism for angiotensin II formation and may play a role in cell communication and signaling in the body.
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Background: An intraoperative transfer of care from one anesthesia provider to another, or handover, may result in information loss and contribute to adverse patient outcomes. In 2019 the authors undertook a quality improvement effort to increase the use of a structured intraoperative handover tool incorporated in the electronic medical record. The authors hypothesized that intraoperative handovers of anesthesia care would be associated with adverse patient outcomes, and that increased use of a structured tool would attenuate this effect.

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Purpose Of Review: Heart transplantation (HT) remains the optimal therapy for patients living with end-stage heart disease. Despite recent improvements in peri-transplant management, the median survival after HT has remained relatively static, and complications of HT, including infection, rejection, and allograft dysfunction, continue to impact quality of life and long-term survival.

Recent Findings: Omics technologies are becoming increasingly accessible and can identify novel biomarkers for, and reveal the underlying biology of, several disease states.

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Rationale: The SubPopulations and InteRmediate Outcome Measures in COPD Study (SPIROMICS) is a prospective cohort study that enrolled 2981 participants with the goal of identifying new chronic obstructive pulmonary disease (COPD) subgroups and intermediate markers of disease progression. Individuals with COPD and obstructive sleep apnea (OSA) experience impaired quality of life and more frequent exacerbations. COPD severity also associates with computed tomography scan-based emphysema and alterations in airway dimensions.

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Importance: Electronic frailty index (eFI) is an automated electronic health record (EHR)-based tool that uses a combination of clinical encounters, diagnosis codes, laboratory workups, medications, and Medicare annual wellness visit data as markers of frailty status. The association of eFI with postanesthesia adverse outcomes has not been evaluated.

Objective: To examine the association of frailty, calculated as eFI at the time of the surgical procedure and categorized as fit, prefrail, or frail, with adverse events after elective noncardiac surgery.

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