Publications by authors named "Amit Rimon"

Antibiotic-resistant pathogens are a growing global issue, leading to untreatable infectious diseases in both humans and animals. Personalized bacteriophage (phage) therapy, the use of specific anti-bacterial viruses, is currently a leading approach to combat antibiotic-resistant infections. The implementation of phage therapy has primarily been focused on humans, almost neglecting the impact of such infections on the health and welfare of companion animals.

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Article Synopsis
  • * The text outlines a protocol for using bacteriophages in a compassionate care context, detailing the process from initial consultation to treatment monitoring.
  • * Important aspects include evaluating phage activity, coordinating multidisciplinary meetings, obtaining ethical approvals, and ensuring proper follow-up to assess the therapy's effectiveness.
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Left ventricular assist devices (LVAD) are increasingly used for management of heart failure; infection remains a frequent complication. Phage therapy has been successful in a variety of antibiotic refractory infections and is of interest in treating LVAD infections. We performed a retrospective review of four patients that underwent five separate courses of intravenous (IV) phage therapy with concomitant antibiotic for treatment of endovascular LVAD infection.

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Using phages as salvage therapy for nonhealing infections is gaining recognition as a viable solution for patients with such infections. The escalating issue of antibiotic resistance further emphasizes the significance of using phages in treating bacterial infections, encompassing compassionate-use scenarios and clinical trials. Given the high specificity of phages, selecting the suitable phage(s) targeting the causative bacteria becomes critical for achieving treatment success.

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Article Synopsis
  • A recent study examined the use of PASA16 phage therapy in 16 patients with stubborn Pseudomonas aeruginosa infections, highlighting the largest compassionate-use series of its kind.
  • The phages were administered either intravenously or topically, showing good results in 13 out of 15 cases, with only minor side effects reported.
  • The findings suggest that combining PASA16 with traditional antibiotics is a promising option for patients who haven't responded to standard treatments, paving the way for future clinical trials.
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Acne vulgaris is a common neutrophil-driven inflammatory skin disorder in which Cutibacterium acnes (C. acnes) is known to play a key role. For decades, antibiotics have been widely employed to treat acne vulgaris, inevitably resulting in increased bacterial antibiotic resistance.

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The fascinating scientific history of phage therapy has been documented in numerous publications. In this study, however, we focus on an angle of the story that hitherto has remained relatively neglected, namely, phage therapy treatments, and the protagonists that conducted these in Mandatory-Palestine and subsequently the state of Israel, as part of a global trend. We complete the story by describing efforts in the new era of phage therapy in present-day Israel.

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Antibiotic-resistant Cutibacterium acnes has been reported worldwide, but data from Israeli patients with acne is currently lacking. This study evaluated the antibiotic susceptibility of C. acnes, isolated from 50 Israeli patients with acne to commonly prescribed antibiotics, using the Epsilometer test (E-test).

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The integrated stress response (ISR) converges on eIF2α phosphorylation to regulate protein synthesis. ISR is activated by several stress conditions, including endoplasmic reticulum (ER) stress, executed by protein kinase R-like endoplasmic reticulum kinase (PERK). We report that ER stress combined with ISR inhibition causes an impaired maturation of several tyrosine kinase receptors (RTKs), consistent with a partial block of their trafficking from the ER to the Golgi.

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A patient with a trauma-related left tibial infection associated with extensively drug-resistant Acinetobacter baumannii and multidrug-resistant Klebsiella pneumoniae was treated with bacteriophages and antibiotics. There was rapid tissue healing and positive culture eradication. As a result, the patient's leg did not have to be amputated and he is undergoing rehabilitation.

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Synopsis of recent research by authors named "Amit Rimon"

  • - Amit Rimon's recent research focuses on innovating phage therapy as a viable treatment for antibiotic-resistant infections in both humans and companion animals, highlighting its potential effectiveness in managing complex cases and emphasizing the need for compassionate-use protocols.
  • - The studies illustrate successful applications of phage therapy in various medical contexts, including implant-associated infections in a cat, LVAD infections, and non-resolving Pseudomonas aeruginosa infections in humans, aiming to enhance clinical outcomes where traditional antibiotics fail.
  • - Rimon advocates for the standardization of phage susceptibility testing and proposes frameworks for the clinical application of phage therapies, reflecting a broader recognition of their role amidst the growing crisis of antibiotic resistance.

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