Downregulation of lncRNA in hypoxia and stem cells is associated with poor disease prognosis in gliomas.

Gliomas are brain tumors associated with high morbidity, relapse and lethality despite improvement in therapeutic regimes. The hypoxic tumor microenvironment is a key feature associated with such poor outcomes in gliomas. The Hypoxia Inducible Factor (HIF) family of transcription factors are master regulators of cellular proliferation, high metabolic rates and angiogenesis via aberrant expression of downstream genes.

Musculoskeletal-based finite element analysis of femur after total hip replacement.

This article evaluates the effect of stress variation on adult femur following total hip replacement using musculoskeletal-based finite element analysis. The aim was to study the changes in stress distribution in the femur after total hip replacement by providing simulated in vivo loading and boundary conditions. The loading and boundary conditions were generated using a musculoskeletal modelling software 'AnyBody' and were applied on femur model, generated from the computed tomography (CT) scan data for standing posture of male patient.