Publications by authors named "Amit Mandal"

The rising demand for fresh and safe food is driving advancements in preservation technologies, with nanoparticles offering a revolutionary solution. These particles extend shelf life, preserve nutritional value, and enhance food safety, aligning with present consumer expectations. This study explores the eco-friendly synthesis, characterization, and application of silk sericin-based silver nanoparticles (SS-AgNPs) for antibacterial and food coating purposes.

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  • Lung carcinoids (L-CDs) are rare neuroendocrine tumors more common in women and categorized into typical (TCs) and atypical carcinoids (ACs), with ACs having worse prognosis.
  • A study of 15 L-CDs revealed two distinct subtypes, L-CD-PanC, likened to pancreatic tumors, and L-CD-NeU, akin to neuroendocrine tumors, differentiated by their genetic and epigenetic profiles.
  • L-CD-PanC tumors showed changes related to metabolic and pancreatic genes, while L-CD-NeU tumors exhibited high mutational loads and specific environmental mutational signatures, suggesting different underlying causes and potential treatment implications.
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Sarcoidosis is an inflammatory disease characterised by non-caseating granulomas of unclear aetiology. Isolated cardiac sarcoidosis (ICS) is rare and occurs when there is granulomatous infiltration of myocardial tissue without evidence of extracardiac sarcoidosis. The heterogeneity in clinical manifestations often presents a diagnostic challenge which leads to delays in treatment initiation.

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Antimicrobial wound dressings offer enhanced efficacy compared to conventional dressing platforms by limiting bacterial infections, expediting the healing process, and creating a barrier against additional wound contamination. The use of silk derived from silkworm cocoons in wound healing applications is attributed to its exceptional characteristics. Compared to mulberry silk, sericin from non-mulberry cocoons has higher water exchange mobility and moisture retention.

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The sericulture industry suffers severe crop losses due to various silkworm diseases, necessitating the development of further technologies for rapid pathogen detection. Here, we report an all-in-one portable biosensor that combines conjugated gold nanoparticles (Au NPs) with an aptamer-based lateral flow assay (LFA) platform for the real-time analysis of sp. and sp.

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A comparative bioinspired reactivity study of new binuclear Zn(II) complexes featuring coordinated thiolate, selenolate, trisulfide and diselenide in relation with (i) the generation of reactive sulfur/selenium species (RSS/RSeS), (ii) the oxygen dependent oxidation and disproportionation of polysulfide (S) to produce sulfite (SO), thiosulfate (SO) and sulfide (S) by sulfur oxygenase reductase (SOR), and (iii) the reaction of S with nitrite (NO) to generate thionitrite (SNO), perthionitrite (SSNO) and nitric oxide (NO), is presented. The binuclear Zn(II)-thiolate/selenolate complexes could react with elemental sulfur to generate RSS/RSeS while similar reactions involving elemental selenium could not generate RSeS. The dizinc(II)-S and the dizinc(II)-Se complexes could react with dioxygen (O) to generate binuclear Zn(II) complexes featuring coordinated thiosulfate (SO) and selenite (SeO), respectively.

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The versatile human commensal bacteria and pathogen Staphylococcus aureus cause several community and hospital-acquired illnesses associated with significant morbidity and death. Antibiotic therapy for S. aureus infections has grown increasingly difficult as the organism has developed a wide spectrum of antibiotic resistance mechanisms.

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Purpose: Patients with locally advanced rectal cancer often require neoadjuvant chemoradiation therapy to downstage the disease, but the response is variable with no predictive biomarkers. We have previously revealed through proteomic profiling that myoferlin is associated with response to radiation therapy. The aims of this study were to further validate this finding and explore the potential for myoferlin to act as a prognostic and/or therapeutic target.

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Foreign bodies are commonly seen in children, here presenting a case of a male adult with an impacted thumb pin in the left lower lobe bronchus. Extraction required fiber-optic bronchoscopy, failure of which led to thoracotomy with bronchotomy.

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  • Septic shock is a serious condition related to sepsis, and current treatments often yield poor outcomes, prompting the exploration of new therapies like CytoSorb, which shows potential for improvement.
  • A consensus was created to guide the use of CytoSorb for septic shock treatment specifically in India, combining expert opinions and evidence from recent literature.
  • After multiple rounds of voting, 11 experts reached agreement on nine key statements related to the use of CytoSorb, highlighting aspects like therapy timing, patient condition prerequisites, and treatment effectiveness.
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  • Silkworms are important for the economy but face significant losses due to diseases during rearing, leading to the need for better disease management strategies.
  • Current reliance on chemical controls raises concerns about antibiotic resistance, highlighting the need for quick and accurate detection of pathogens in silkworms to prevent disease spread.
  • This study examines various silkworm diseases and their causative agents, comparing traditional diagnostic methods to advanced biosensing technologies, particularly focusing on lateral flow assay-based biosensors for effective pathogen detection.
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The rapid emergence of antimicrobial resistance (AMR) in has reinforced its status as a foodborne pathogen of significant public health concern. Resistant is typically transferred to humans via the consumption of contaminated animal products, particularly poultry. The genes associated with antimicrobial resistance in spp.

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Background: QRS fragmentation (fQRS) is a depolarization disorder that can be detected on routine electrocardiography (ECG). Current evidence suggests that fQRS is a prognosticator of adverse cardiovascular events. This study aimed to assess the relationship between fQRS and all-cause mortality in critically unwell coronavirus disease 2019 (COVID-19) patients and to investigate the significance of associated abnormalities on echocardiography.

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  • A rod-shaped Gram-negative bacterium from the genus has become a significant pathogen for silkworms, showing multi-drug resistance due to excessive antimicrobial use in sericulture.
  • These multi-drug resistant strains can pose health risks to humans through direct contact or contaminated silkworm feces.
  • Researchers sequenced the genome of a strain isolated from infected silkworms, revealing important genetic information that could help understand antimicrobial resistance and the bacterium's virulence.
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Polypharmacotherapy is an ever-increasing issue with an ageing patient population. Anticholinergic medications make up a large proportion of patient medication but cause significant side effects, contributing to well-documented issues within the older population and in hospital medicine. This review explores the documented impact of anticholinergic burden in older surgical patients on postoperative delirium, infection, length of stay and readmission, urinary retention, ileus and mortality.

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Comparative reactivity of a series of new Zn(II) and Fe(II) compounds, [(Py2ald)M(ER)] (E = S, R = Ph: M = Zn, 1aZn; M = Fe, 1aFe; E = S, R = 2,6-Me-CH: M = Zn, 1bZn; M = Fe, 1bFe; E = Se, R = Ph: M = Zn, 2Zn; M = Fe, 2Fe), and [(Py2ald)M] (M = Zn, 5Zn; M = Fe, 5Fe) is presented. Compound 1aZn could react with nitrite (NO) to produce [(Py2ald)Zn(ONO)] (3Zn), which, upon treatment with thiols and PhSeH (proton source), could regenerate either 1aZn/ and  respectively, along with the production of nitric oxide (NO) where the yield of NO increases in the order BuSH ≪ PhCHSH < PhSH < PhSeH. In contrast to this, 1aFe, 2Fe and 5Fe could affect the direct reduction of NO in the absence of protons to generate NO and [{(Py2ald)(ONO)Fe}-μ-O] (8Fe).

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Malaria prevalence has become medically important and a socioeconomic impediment for the endemic regions, including Purulia, West Bengal. Geo-environmental variables, humidity, altitude, and land use patterns are responsible for malaria. For surveillance of the endemic nature of Purulia's blocks, statistical and spatiotemporal factors analysis have been done here.

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The infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) resulted in a pandemic with huge death toll and economic consequences. The virus attaches itself to the human epithelial cells through noncovalent bonding of its spike protein with the angiotensin-converting enzyme-2 (ACE2) receptor on the host cell. Based on studies we hypothesized that perturbing the functionally active conformation of spike protein through the reduction of its solvent accessible disulfide bonds, thereby disintegrating its structural architecture, may be a feasible strategy to prevent infection by reducing the binding affinity towards ACE2 enzyme.

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The intricate, tightly controlled mechanism of wound healing that is a vital physiological mechanism is essential to maintaining the skin's natural barrier function. Numerous studies have focused on wound healing as it is a massive burden on the healthcare system. Wound repair is a complicated process with various cell types and microenvironment conditions.

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Colorectal cancer possesses marked intratumoral heterogeneity. While subclonal interactions between Vogelstein driver mutations have been extensively studied, less is known about competitive or cooperative effects between subclonal populations with other cancer driver mutations. FBXW7 is a cancer driver mutation which is present in close to 17% of colorectal cancer cells.

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  • Right heart thrombus in transit is a serious medical condition where a blood clot travels from deep veins to the right side of the heart and poses a high risk of pulmonary embolism.
  • This condition has a mortality rate exceeding 40% and is often linked to complications from peripherally inserted central catheters (PICCs).
  • The cases presented emphasize the need for doctors to quickly use imaging techniques to diagnose potential issues in patients with PICCs, especially those with increased risk of venous thrombosis, while also stressing the importance of optimizing catheter insertion techniques.
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Introduction: Polypharmacy is a growing phenomenon associated with adverse effects in older adults. We assessed the potential confounding effects of cumulative anticholinergic burden (ACB) in patients who were hospitalized with falls.

Methods: A noninterventional, prospective cohort study of unselected, acute admissions aged ≥ 65 years.

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