Synopsis of recent research by authors named "Amit Ketkar"
- Amit Ketkar's research primarily focuses on the roles of DNA polymerases and their interactions with specific DNA structures, particularly G-quadruplex motifs, and the implications these interactions have for DNA damage tolerance and repair processes in various cell types.
- His work on Rev1 DNA polymerase across species has highlighted conserved molecular mechanisms that enable selective binding to G-quadruplexes, further influencing translesion DNA synthesis activities.
- Ketkar's studies also explore the impact of small-molecule inhibitors on human DNA polymerases, revealing potential therapeutic targets for enhancing the efficacy of chemotherapeutic agents in cancer treatment.
