Hematological and Biochemical Responses of Newly Formulated Primary Root Canal Obturating Material: An In Vivo Study.

Background and objective Any drug or medicinal agent, when implanted into the body, gets biotransformed by various organ systems and the toxic byproducts of this process alter the normal physiological process. In this experimental study, we aimed to quantify the safety of newly formulated primary root canal obturating material by investigating the hematological and biochemical parameters related to liver function. Methodology Forty-eight Wistar rats (weighing 250-350 grams) were classified into three groups (n=16) through random allocation.

Sentiment analysis of COVID-19 social media data through machine learning.

Pandemics are a severe threat to lives in the universe and our universe encounters several pandemics till now. COVID-19 is one of them, which is a viral infectious disease that increased morbidity and mortality worldwide. This has a negative impact on countries' economies, as well as social and political concerns throughout the world.

Automating fake news detection using PPCA and levy flight-based LSTM.

In recent years, rumours and fake news are spreading widely and very rapidly all over the world. Such circumstances lead to the propagation and production of an inaccurate news article. Also, misinformation and fake news are increased by the user without proper verification.

Upsurge of chikungunya cases in Uttar Pradesh, India.

Background & Objectives: Chikungunya (CHIK) re-emerged in India in 2006 after a gap of three decades. In Uttar Pradesh (UP), <100 confirmed cases per million were reported during this outbreak. Based on an upsurge of CHIK cases at UP, this retrospective study was conducted to investigate clinical and serological profile of CHIK cases in UP.

Human parvovirus 4: An emerging etiological agent in cases presenting with influenza like illness.

This study was planned to study the association of parvovirus 4 (PARV4) with Influenza-like illness (ILI). A total of 1111 patients with a clinical diagnosis of ILI and 220 healthy controls were tested for Influenza A/HINI/and H3N2, Influenza B, and PARV4. Further sequencing was done to analyze the genotype distribution of parvovirus 4.

Management of Grade IV Pressure Ulcers With a Novel Negative Pressure Device in Traumatic Paraplegia Subjects.

Introduction Pressure ulcers (PUs) are a major health problem for bedridden patients or persons with reduced mobility; individuals with spinal cord injury (SCI) are more prone to developing pressure ulcers. The purpose of this study was to determine the efficacy of a novel negative pressure wound therapy (NPWT) system for the treatment of Grade IV PUs. Methods A total of 34 SCI patients with Grade IV PUs were divided into two groups: 17 cases were managed by our bellows-powered negative pressure device (NPD) and 17 received wet-to-moist gauze dressing as standard wound care.

Molecular characterization of hepatitis A virus circulating in Uttar Pradesh, India: A hospital-based study.

Background & Objectives: Hepatitis A is prevalent worldwide and is among the leading cause of acute viral hepatitis in India. Major geographical differences in endemicity of hepatitis A are closely related to hygienic and sanitary conditions and other indicators of the level of socio-economic development. The present study was aimed to know the seropositivity prevalence and predominant circulating strain of HAV in a north India.

Human Parvovirus 4: A harmless bystander or a pathogen of severe acute respiratory illness.

Introduction: Severe Acute Respiratory Infection (SARI) is an important cause of morbidity and mortality worldwide, caused by a large number of viral and bacterial agents. PARV4 is a recently identified virus detected in human blood and variety of tissues, but its disease association with SARI could not be established.

Objective: In the present case control study, we aim to investigate the association of PARV4 with SARI.

Aetiology of acute encephalitis syndrome in Uttar Pradesh, India from 2014 to 2016.

Background & Objectives: It is imperative to know the aetiology of acute encephalitis syndrome (AES) for patient management and policy making. The present study was carried out to determine the prevalence of common aetiological agents of AES in Uttar Pradesh (UP) state of India.

Methods: Serum and/or CSF samples were collected from AES patients admitted at Gandhi Memorial and Associated Hospital, King George's Medical University, Lucknow, a tertiary care centre, UP during 2014-16.

Impact of Root Dentin Thickness on the in vitro Compressive Strength of Teeth treated with Recent Post and Core Systems.

Introduction: Endodontically treated teeth dry with time, and its dentin undergoes changes making the teeth brittle and friable. The main function of a post is to strengthen or reinforce a weakened root. However, doing a post and core frequently requires the removal of sound tooth tissue.

Expression of MMP-8 in Pressure Injuries in Spinal Cord Injury Patients Managed by Negative Pressure Wound Therapy or Conventional Wound Care: A Randomized Controlled Trial.

Purpose: The purpose of this study was to assess the level of matrix metalloproteinase-8 (MMP-8) and wound-healing outcome measures (length, width, and depth, exudate amount, and tissue type) in pressure injuries (PIs) of spinal cord-injured patients treated with negative pressure wound therapy (NPWT) using a novel negative pressure device versus PI treated with wet to moist gauze (conventional wound care).

Design: Randomized controlled trial.

Subjects And Setting: Forty-four spinal cord-injured patients with stage 3 and 4 sacral PI participated in the study.

A non-randomised, controlled clinical trial of an innovative device for negative pressure wound therapy of pressure ulcers in traumatic paraplegia patients.

The conventional methods of treatment of pressure ulcers (PUs) by serial debridement and daily dressings require prolonged hospitalisation, associated with considerable morbidity. There is, however, recent evidence to suggest that negative pressure wound therapy (NPWT) accelerates healing. The commercial devices for NPWT are costly, cumbersome, and electricity dependent.