A pipeline for identifying guide RNA sequences that promote RNA editing of nonsense mutations that cause inherited retinal diseases.

Adenosine deaminases acting on RNA (ADARs) are endogenous enzymes catalyzing the deamination of adenosines to inosines, which are then read as guanosines during translation. This ability to recode makes ADAR an attractive therapeutic tool to edit genetic mutations and reprogram genetic information at the mRNA level. Using the endogenous ADARs and guiding them to a selected target has promising therapeutic potential.

[CONTROLLING THE WAY OF THINKING, THE MENTAL STRESS AND THE ATTENTION ABILITY TO ALLEVIATE THE TINNITUS NUISANCE BY MEANS OF COGNITIVE BEHAVIORAL THERAPY (CBT)].

Introduction: About 15% of the population suffers from tinnitus but only in 2-3% of cases the tinnitus is severe with great functioning difficulties. The distress caused by tinnitus is mostly caused by the reaction to the tinnitus and not by the tinnitus itself.

Aims: Methods to alleviate the tinnitus distress are presented with emphasis on the importance of the primary detailed explanation to the patient.

Identification of exceptionally potent adenosine deaminases RNA editors from high body temperature organisms.

The most abundant form of RNA editing in metazoa is the deamination of adenosines into inosines (A-to-I), catalyzed by ADAR enzymes. Inosines are read as guanosines by the translation machinery, and thus A-to-I may lead to protein recoding. The ability of ADARs to recode at the mRNA level makes them attractive therapeutic tools.