Advances and challenges in the high-pressure rheology of complex fluids.

Complex fluids and soft materials are ubiquitous in nature and industry. In industrial processes, these materials often get exposed to high hydrostatic pressures. Some examples include polymer melts, crude oils, gas hydrates, food systems, foams, motor oils, lubricants, etc.

Rapid and sensitive detection of potato cyst nematode by loop-mediated isothermal amplification assay.

Unlabelled: Cyst nematodes of the species and are devastating parasites of the potato crop. Early detection of cyst nematodes in the field is critical for adopting an appropriate management strategy. A specific and sensitive loop-mediated isothermal amplification (LAMP) assay using four oligonucleotide primers has been developed to amplify the internal transcribed spacer region (ITS) of ribosomal DNA of potato cyst nematode The PCN-LAMP reaction could be completed within 75 min at 68 °C followed by termination at 85 °C for 7 min.

Identification of Galtox, a new protein toxin from Photorhabdus bacterial symbionts of Heterorhabditis nematodes.

The Gram-negative bacteria Photorhabdus lives in a symbiotic relationship with the insect-pathogenic Heterorhabditis nematodes and produces numerous hydrolytic enzymes, secondary metabolites and protein toxins. Seven Photorhabdus strains were previously isolated from the Heterorhabditis nematodes collected from different geographical regions of India. The strains IARI-SGMG3, IARI-SGHR2, IARI-SGHR4, IARI-SGMS1 and IARI-SGGJ2 were identified as P.

Two step yielding in soft materials.

A review is presented on the topic of two-step yielding observed in complex fluids that cover a broad variety of materials ranging from colloidal gels, attractive glasses, emulsions, suspensions, and several commercial paste-like materials. The common features in various systems displaying two-step yielding behavior are the presence of two characteristic forces between the interacting particles or two varying representative length or time scales. This focused review aims to provide physical insights, mechanistic understanding of the two-step yielding and other associated rheological consequences of this nonlinear behavior.

Rheology of starch dispersions at high temperatures.

In the food industry, many food products experience extreme processing conditions of high temperature and high shear stresses. The measurements of sample behavior for water-based formulations above 100°C is extremely challenging due to changes in material composition from the boiling of volatile ingredients. We have developed a high-sensitivity, pressurized starch pasting cell (up to 5 bar) which utilizes a design free of mechanical bearings and seals, resulting in an order-of-magnitude improvement in torque sensitivity (1 μN.

Clinical, Economic, and Humanistic Burden Associated With Delayed Diagnosis of Axial Spondyloarthritis: A Systematic Review.

Introduction: Few studies have evaluated the impact of delayed diagnosis of axial spondyloarthritis (axSpA) on the overall burden of disease. The objective of this review was to evaluate the available literature on the clinical, economic, and humanistic burden of delayed diagnosis in patients with axSpA.

Methods: This systematic literature review was conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Relative value assessment: characterizing the benefit of oncology therapies through diverse survival metrics from a US perspective.

Objectives: The introduction of innovative, high-cost oncology treatments, coupled with mounting budgetary pressures, necessitates value trade-offs across cancer types. Defining value is critical to informing decision-making. A cost-value analysis tool was used to assess relative clinical value from a US perspective using multiple outcome metrics for a variety of metastatic cancers.

Rheological predictions of sensory attributes of lotions.

Complex behavior of 33 commercial lotions was investigated in order to identify correlations between laboratory instrumental measurements and sensory attributes of these products. Sensory attributes were evaluated by trained panelists. Six attributes were identified as potentially related to rheology, which belong to three main sensory categories: appearance, pickup, and rub out.

Indirect treatment comparison of dabrafenib plus trametinib versus vemurafenib plus cobimetinib in previously untreated metastatic melanoma patients.

Background: Metastatic melanoma is an aggressive form of skin cancer with a high mortality rate and the fastest growing global incidence rate of all malignancies. The introduction of BRAF/MEK inhibitor combinations has yielded significant increases in PFS and OS for melanoma. However, at present, no direct comparisons between different BRAF/MEK combinations have been conducted.