Publications by authors named "Amit Adlakha"
Invasive pulmonary aspergillosis is a lethal opportunistic fungal infection in transplant recipients receiving calcineurin inhibitors. We previously identified a role for the calcineurin pathway in innate immune responses to and have used exogenous interferon-gamma successfully to treat aspergillosis in this setting. Here we show that calcineurin inhibitors block dendritic cell maturation in response to impairing the Th1 polarization of CD4 cells.
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- People with HIV (PWH) admitted to ICUs have a higher risk of mortality, with this study analyzing data from 2000-2019 to focus on 1-year post-ICU admission mortality trends.
- Among 221 PWH admitted, 108 died within a year, but the overall 1-year mortality risk decreased by 10% annually, adjusted to 7% when accounting for various factors like age and CD4+ count.
- The findings stress a decline in post-ICU mortality rates over time, indicating a need for further research and ongoing care support for PWH after they're discharged from the hospital.
Article Synopsis
- The study analyzes ICU admission outcomes for people with HIV (PWH) at a UK referral center from 2000 to 2019, highlighting a significant decrease in mortality rates over the years.
- Among 221 PWH, the study found in-ICU mortality at 29% and in-hospital mortality at 38.5%, with lower respiratory tract infections being the most common reason for admission.
- Despite adjustments for various patient factors, mortality rates continued to decline, suggesting improvements in critical care and patient health due to advances in treatment.
Article Synopsis
- Late diagnosis of HIV significantly contributes to higher in-ICU mortality rates, with 28% of patients having recent late diagnosis linked to worse health outcomes.
- A study analyzed data from 2000 to 2019, finding that in-ICU mortality was 27%, with those diagnosed late facing a 38% mortality rate compared to 22% for those diagnosed earlier.
- The research indicates that 17.08% of in-ICU deaths are attributable to recent late diagnosis, underlining the need for enhanced HIV testing and earlier diagnosis in healthcare.
Tourism is one of the lifelines in nations for their strong economy. Through the expansion of tourism industry, enormous amounts of plastic materials are disposed that have detrimental effects on environment, animal and human health. The present study demonstrates the role of tourists on generation of plastic waste and further statistical approach was used to investigate the impact of knowledge, behaviour, and attitude of tourists towards generation of plastic waste.
View Article and Find Full Text PDFThe Swachh Bharat Mission undertaken by the Government of India (GoI) has been successful in accomplishing this objective within a short period thereby catalyzing governance following Sustainable Development Goals (SDGs). It is the responsibility of any democratic nation to ensure that its citizens have universal access to adequate and equitable sanitation. The key approach adapted to igniting a change in sanitation behavior rather than constructing toilets.
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