Publications by authors named "Amirtham Jacob Appadurai Ranjitsingh"
Prevalence of extended-spectrum β-lactamase-producing multidrug-resistant Escherichia coli among isolates from community-acquired infections and in silico structural modeling of an ESBL protein.
Krishnamoorthy Rajapandiyan Subbarayan Shanthi Periyasamy Vijayalakshmi Pitchai Daisy Munusamy Murugan Amirtham Jacob Appadurai Ranjitsingh
Microb Drug Resist
April 2014
Article Synopsis
- Escherichia coli is a significant cause of bacterial infections among tea tribe patients in Assam, India, with a study revealing high rates of multidrug resistance (MDR) and the presence of extended-spectrum β-lactamases (ESBLs).
- Among 148 E. coli strains analyzed, there was a notable resistance to multiple antibiotics, including ampicillin and amoxicillin, and 26% of the isolates were identified as ESBL producers, contributing to the increasing resistance.
- The study also utilized molecular modeling to understand the structure of ESBL proteins, emphasizing the role of previous exposure to low-quality antibiotics in rising drug resistance and aiding in future drug targeting strategies.