Gut microbiota composition and type 2 diabetes: Are these subjects linked Together?

Purpose: Evidence suggests that changes in the composition of gut microbiota may be linked to metabolic disorders including type 2 diabetes (T2D). The present study aims to evaluate the compositional changes of the intestinal microbiota in patients with T2D as compared to healthy individuals.

Methods: In this case-control study, there were 18 T2D patients and 18 healthy individuals who served as controls.

Efficacy and treatment outcome of infected patients with pulmonary : A systematic review.

Background: () is a non-tuberculosis bacterium with a highly prevalent that is transferred by aerosols from water and soil resources to the respiratory system. is one of the main species responsible for NTM pulmonary disease.

Methods: Web of Science, Scopus, and PubMed databases were systematically explored.

Effectiveness of photodynamic therapy on the treatment of chronic periodontitis: a systematic review during 2008-2023.

Objective: This study investigated the effect of photodynamic therapy on chronic periodontitis patients and then evaluated the microbial, immunological, periodontal, and clinical outcomes. The significant effects of photodynamic therapy obtained by and studies have made it a popular treatment for periodontal diseases in recent years. Photodynamic therapy is a novel bactericidal strategy that is stronger, faster, and less expensive than scaling and root planing.

Virulence Genes and Biofilm Formation Among Legionella pneumophila Isolates Collected from Hospital Water Sources.

Legionella pneumophila can be transmitted to people, especially immunocompromised patients, via hospital water pipe systems and cause severe pneumonia. The aim of our study was to investigate the presence of major virulence factor genes, ability of biofilms formation, and correlation between presence of Legionella isolates and temperature, pH, and residual chlorine of water. Hundred water samples were collected from nine hospitals in Tehran, Iran.

Iron Oxide Nanoparticles Conjugated to Thiosemicarbazone Reduce the Survival of Cancer Cells by Increasing the Gene Expression of in Lung Cancer A549 Cells.

Background: Cancer cells have a higher demand for iron to grow and proliferate. A new complex of iron nanoparticles and thiosemicarbazones was synthesized. Confirmation tests included UV-visible, scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), Fourier transform infrared (FTIR), X-ray diffraction (XRD) and zeta potential.

Anti-biofilm Activity of a Lytic Phage Against Vancomycin-Resistant .

Background & Objective: This study aims to isolate a lytic bacteriophage against planktonic  V583 culture and evaluate its ability to disrupt and inhibit biofilm.

Methods: An anti- phage was isolated from sewage and visualized by electron microscopy, the vB_EfsS_V583 (V583) host range was determined by spot test on 13 clinical strains. Inhibition and degradation experiments were designed to investigate the effect of phage on biofilm.

Association of perturbation of oral bacterial with incident of Alzheimer's disease: A pilot study.

Objective: This case-control study was designed to compare the composition of the predominant oral bacterial microbiome in Alzheimer's disease (AD) and control group.

Subject: A total of 30 adult participants (15 AD and 15 healthy individuals) were entered in this study. The composition of oral bacterial microbiome was examined by quantitative real-time polymerase chain reaction (qPCR) using bacterial 16S rDNA gene.

Association between virulence factors and biofilm formation in Enterococcus faecalis isolated from semen of infertile men.

Problem: Enterococcus faecalis is a common microbial semen contaminant. Although virulence factors and biofilm formation have often been analyzed in Enterococcus spp., there is little information about these features in isolates obtained from the genitourinary tract.

Toxin gene profiles and antimicrobial resistance of infection: a single tertiary care center study in Iran.

Background And Objectives: Due to the reduced susceptibility of clinical strains in hospitals to various antimicrobial agents, the importance of antimicrobial susceptibility testing (ASTs) has increased. This study aimed to investigate the toxin gene profiles and the antimicrobial resistance of isolated from hospitalized patients suspected of having infection (CDI) in Tehran, Iran.

Materials And Methods: The stool samples were obtained from a hospitalized patients.

Using the PCR and Blood Agar in Diagnosis of Semen Bacterial Contamination of Fertile and Infertile Men.

Background: One of the causes of male infertility is Genital tract infections (GTI). Considering the importance of GTI, widespread recognition of them seems necessary. we aimed to characterize and compare semen microbial populations in fertile and infertile men who referred to an infertility clinic in Yazd, Iran.

Biological characteristics and anti-biofilm activity of a lytic phage against vancomycin-resistant .

Background And Objectives: An important leading cause of the emergence of vancomycin-resistant enterococci, especially , is the inefficiency of antibiotics in the elimination of drug-resistant pathogens. Consequently, the need for alternative treatments is more necessary than ever.

Materials And Methods: A highly effective bacteriophage against vancomycin-resistant called vB-EfmS-S2 was isolated from hospital sewage.

Investigating the Efficiency of Recombinant FliC-Loaded Spores in Mice Immunization against Serovar Typhi.

Background: Bacterial spores are among the most efficient vaccine delivery vehicles. Because of their safety and efficacy, spores are increasingly used in this regard. The negatively charged surfaces of the spores allow antigens to be adsorbed onto these structures.

Antibacterial effect of carbon nanotube containing chemical compounds on drug-resistant isolates of .

Background And Objectives: is recognized as an important pathogen responsible for serious infections causing episodes of hospital infection. Carbon nanotubes (CNTs) have recently emerged as superior materials against antibiotic-resistant bacteria. In this study, a new chemical compound was designed in order to combat infections.

Molecular characterization of polymorphisms among strains isolated from burn patients' wounds.

is one of the most common reasons for nosocomial infections. Given the high morbidity and mortality, as well as the cost of management, particularly in developing countries, burn injuries are considered important health concerns. Owing to the increased rate of resistance against antibiotics, this study aimed to isolate strains from burn patient's wounds by analyzing antibiotic susceptibility and genetic profiling.

[ Tc-HYNIC/EDDA]-MccJ25 antimicrobial peptide analog as a potential radiotracer for detection of infection.

Bacterial infections are a serious risk to human health, and therefore techniques for early detection of infectious foci need to be further developed to begin treatment quickly and achieve better results. Antimicrobial peptides labeled with gamma-emission radio nuclides are important diagnostic radiotracers in nuclear medicine. This study was conducted to evaluate the potential of a Tc-labeled MicrocinJ25 (MccJ25) antimicrobial peptide analog for early detection of infection.

Comparison of Three Different Therapies for Cutaneous Leishmaniasis and Identification of the Etiologic Isolates in Isfahan, Iran.

Background: In Iran, zoonotic and anthroponotic cutaneous leishmaniasis (CL) are caused by Leishmania major and L. tropica respectively. Despite extensive studies, no effective therapies have ever been reported for CL.

Design, Expression and Purification of IgG4 Immunoreactive Protein (NIE) in .

Background: Strongyloidiasis is a public health concern in northern regions of Iran, caused by . Auto-infection cycle can be resulted in high parasitic load, especially in immunocompromised hosts. Because of low sensitivity of stool culture and stool-based microscopy techniques, detection of antibodies in patient's sera can be an alternative diagnostic technique for detection of the nematode.

The effect of improved formulation of chitosan-alginate microcapsules of Bifidobacteria on serum lipid profiles in mice.

Background: Probiotics have been associated with many beneficial effects in human digestive physiology. The aim of this study was to evaluate the effect of improved formulation of chitosan-alginate microcapsules of Bifidobacterium strains on serum triglycerides, cholesterol, HDL, and LDL in mice.

Methods: Five approved probiotic strains of Bifidobacterium were tested for anti-proliferative effect and interleukin-8 induction on HT-29 cell lines.

The Construction of Carbon Nanotubes Containing an Anti-Bacterial Chemical Component and its Effect on MDR and XDR Isolates of .

Background: is an opportunistic human pathogen that causes severe acute and chronic nosocomial infections, especially in immunocompromised burn patients. and can lead to severe mortality and morbidity. The emergence of antibiotic resistant infections has created significant challenges in treating these patients.

Species Variety, Antibiotic Susceptibility Patterns and Prevalence of Enterotoxin Genes in Staphylococci Isolated from Foodstuff in Central Iran.

Background: The presence and diversity of species and their enterotoxin-encoding genes in foodstuffs have not been comprehensively studied in some developing countries. This study aimed to assess the frequency of spp. and their related virulence factors in foodstuffs in Isfahan, Iran.

How Phages Overcome the Challenges of Drug Resistant Bacteria in Clinical Infections.

Nowadays the most important problem in the treatment of bacterial infections is the appearance of MDR (multidrug-resistant), XDR (extensively drug-resistant) and PDR (pan drug-resistant) bacteria and the scarce prospects of producing new antibiotics. There is renewed interest in revisiting the use of bacteriophage to treat bacterial infections. The practice of phage therapy, the application of phages to treat bacterial infections, has been around for approximately a century.

The role of the gene in antimicrobial resistance of .

Background And Objectives: isolates that produce carbapenemase (KPC) have become a grave concern for the treatment of infections. KPC-producing strains are not only able to hydrolyze carbapenems but are also resistant to a variety of β-lactam and non-β-lactam antibiotics. The present study evaluated the prevalence of in infections and determined the antimicrobial susceptibility of the isolates.

Prevalence of vaginolysin, sialidase and phospholipase genes in isolates between bacterial vaginosis and healthy individuals.

is considered as the predominant microorganism found in bacterial vaginosis (BV). The aim of this study was to evaluate the prevalence of virulence factors in associated with BV or non-BV cases and their correlations with this disorder. A total of 102 vaginal specimens were collected from patients during their visit to Akbar Abadi hospital in Tehran, Iran.