Publications by authors named "Amirhossein Shekarriz"
Article Synopsis
- The study focused on the anti-cancer effects of hypericin and naringenin on the Y79 retinoblastoma cell line, primarily investigating apoptosis, which is the process of programmed cell death.
- Using XTT and trypan blue assays, researchers determined the cytotoxic effects of both compounds, finding that hypericin was more effective in inducing cell death compared to naringenin after 24 and 48 hours of treatment.
- Real-time PCR analysis revealed that hypericin influences the Bax/Bcl-2 ratio to promote apoptosis, while naringenin did not produce a significant increase in the Bax levels, indicating no synergistic effect when both compounds were used together.
Background: Hepatocellular carcinoma is the most common type of liver cancer which arises from the main cells in the liver. We address many studies investigating anti-cancer role of hypericin, however the proposing corresponding molecular pathway seems to be still a debate. Therefore, the present study aimed to evaluate the apoptotic effect of hypericin on the Huh7 as the liver cancer cell line and its relation with the gate keeper gene P53.
View Article and Find Full Text PDFBackground: Osteosarcoma (OS) is known as the malignant tumors in the bone. Cyanidin 3-OGlucoside (C3G) has a potential to induce the apoptotic cell death in different cancer cells; however, the mechanisms of action for C3G have not been clarified yet.
Objective: In this study, the apoptotic effects of C3G on three different osteosarcoma cell lines including Saso-2, MG-63, and G-292 (clone A141B1) were investigated.