A Metal-Organic Framework-Based Colorimetric Sensor Array for Transcutaneous CO Monitoring via Lensless Imaging.

Transcutaneous carbon dioxide (TcPCO2) monitoring provides a non-invasive alternative to measuring arterial carbon dioxide (PaCO2), making it valuable for various applications, such as sleep diagnostics and neonatal care. However, traditional transcutaneous monitors are bulky, expensive, and pose risks such as skin burns. To address these limitations, we have introduced a compact, cost-effective CMOS imager-based sensor for TcPCO2 detection by utilizing colorimetric reactions with metal-organic framework (MOF)-based nano-hybrid materials.

Optical sensors for transdermal biomarker detection: A review.

This review has explored optical sensors and their important role in non-invasive transdermal biomarker detection. While electrochemical sensors have been thoroughly studied for biomarker tracking, optical sensors present a compelling alternative due to their high sensitivity and selectivity, multiplex capabilities, cost-efficiency, and small form factor. This review examines the latest advancements in optical sensing technologies for transdermal biomarker detection, such as colorimetry, fluorescence, surface plasmon resonance (SPR), fiber optics, photonic crystals, and Raman spectroscopy.