PEDUNCULATED SUPRACLAVICULAR FASCIOCUTANEOUS FLAP FOR RECONSTRUCTION OF POST-LARYNGECTOMY PHARYNGOSTOMAS.

The aim of the study was to analyze the effectiveness of the repair of post-laryngectomy pharyngostomas using supraclavicular flap. In a group of 4 patients treated in 2018-2021. in 2 (50.

[The role of computed tomography in benign tumors and tumor-like lesions of the bones].

The results of these studies coincided with domestic and foreign literature. X-ray, CT and MRI findings were compared with postoperative assessment histological data. Usefulness of x-ray, CT and MRI studies amounted to respectively 57,1±6,5%, 85,0±3,7% and 75,1±5,1%.

Breast endocrine cancer.

Mammary carcinoid is an uncommon neoplasm. It is not clear whether mammary carcinoid is a distinct clinical entity or a variant of conventional breast carcinoma. It is well-known that neuroendocrine elements can be demonstrated in ductal and lobular carcinoma.

[Surgical treatment for pathologic fractures of long tubular bones in metastatic cancer].

Surgery for pathological fracture of long tubular bones associated with metastatic cancer was given to 77 patients (1993-2000): segmental resection with endoprosthetic replacement - 26; intramedullary osteosynthesis - 17; perosseous extrafocal osteosynthesis - 34. No intraoperative complication was reported. Infection-related postoperative complications, mainly in perosseous osteosynthesis, developed in 5 (7%).

[Infectious complications after prosthesis implantation in patients with bone tumors].

Data on the retrospective analysis of 245 cases of endoprosthetic replacement of bones and major joints are presented. Intraprosthetic infection-related complications were reported in 11%. They developed within 3 months in 64% and their frequency was significantly higher in cases of repeat surgery, resection of proximal tibia with subsequent endoprosthetic replacement of defective knee joint as well as adjuvant polychemotherapy.

The first experience with minimally invasive phlebectomy using the TriVex system.

Presented herein is the first experience gained in Russia with endoscopic transillumination phlebectomy (ETP). The aim of the study was to evaluate the clinical effectiveness and advantages of ETP versus traditional combined phlebectomy (TCP). Altogether 94 patients with different forms of lower extremity varicosis were operated on.

Breast reconstruction with the internal mammary artery pedicled fasciocutaneous island flap: description of a new flap.

Postburn skin contracture of the inframammary sulcus is a commonly encountered problem, especially in pubescent girls. Release of these contractures is commonly performed by split-thickness skin grafts, which necessitate further operations as the child grows. If the contracture of the inframammary sulcus is only one-sided, then the inframammary tissues of the contralateral breast can be used for reconstruction with the fasciocutaneous island flap.

[The comparative characteristics of anesthesia methods in operations for tumors located on the extremities].

Seventy patients operated on for malignant tumors located in the extremities have been examined, 30 of them were operated on under conduction anesthesia. The adequacy of anesthesia was assessed using clinical metabolic and electrophysiological techniques. Evident advantages of conduction anesthesia over general anesthesia during short-term interventions have been substantiated.

[The characteristics of eicosanoid synthesis in osteogenic sarcoma in children at puberty].

Levels of prostaglandin E (PGE), prostaglandin F2 alpha, prostacyclin A2, thromboxan B2 and leucotriene B4 assayed radioimmunologically were compared in 42 samples of osteogenic sarcoma and 22 samples of benign tumors and tumor-like lesions from children at the pubertal period. In osteogenic sarcoma samples, PGE and prostaglandin F2 alpha levels were higher than those of thromboxan B2, prostacyclin A2 and leucotriene B4. Osteogenic sarcoma revealed higher levels of the eicosanoids as compared to benign tumors and tumor-like lesions of the bone.

[Sex and pituitary hormone secretion in normal-height and tall adolescents with primary osteogenic sarcoma].

The paper deals with a comparison of basal levels of secretion of total testosterone (T) and estradiol-17 beta (E2), their free and albumin and sex-steroid-binding globulin fractions as well as LH, FSH, prolactin and STH in blood serum of 60 normal height and 60 tall healthy adolescents and those with primary osteogenic sarcoma of bones at different stages of puberty. The study established a significantly higher level of testosterone and free androgen index and a lowered concentration of sex-steroid-binding globulin in blood serum of both normal and tall adolescent patients with osteogenic sarcoma at different stages of puberty. No significant differences were found in said indexes of estrogens between sarcoma patients and a specific group chosen for comparison, as far as physical status is concerned.

IIB osteosarcoma. Current management and survival statistics in the USSR.

Three hundred and ninety-three patients with IIB osteosarcoma were treated at the author's institution between 1955 and 1986. In the first stage of the study, 88 patients were treated with surgery only. The five-year disease-free survival rate was 7%.

[Polypeptide growth factors and their interrelation with hormones in the blood plasma of patients with primary bone tumors].

A relationship between blood plasma levels of polypeptide growth factors and those of peptide and sex steroid hormones, as assayed radioimmunologically, was studied in 91 patients with bone tumors of various histology and 45 healthy donors. The levels of insulin-like growth factor (IGF-1) and somatotropic hormone were significantly higher in cases of chondrosarcoma and patients suffering osteogenic sarcoma in the late puberal period as compared to controls and cases of fibrous histiocytoma, giant-cell tumor, benign tumors and tumor-like lesions of the bone. The peak levels of IGF-1, somatotropic hormone and insulin were registered in osteogenic sarcoma patients who developed pulmonary metastases either in the course or after the completion of combined treatment.

[Prognostic factors in parosteal sarcoma].

Principles of evaluating prognosis in parosteal sarcoma were developed with respect to clinical and morphological pattern of disease and type of treatment. A mathematical model for making prognosis and a procedure for its multifactorial analysis were suggested.

[Determining groups at risk of cancer in skin diseases].

The frequency of subsequent tumor development in patients suffering from acquired ichthyosis and Darier's erythema as well as cases of concurrent dermatosis and malignant diseases was studied. The clinical course of said skin diseases was followed versus the effectiveness of tumor treatment. Acquired ichthyosis was found to be associated predominantly with neoplasms while the incidence of Darier's erythema was not.

[Experience with thermoradiotherapy of malignant tumors].

The authors analyzed immediate, short-term results of thermoradiotherapy of 112 patients and radiotherapy alone of 91 patients (control group). All had tumors of different sites. Local hyperthermia used as an adjuvant to radiotherapy made it possible to increase the frequency of complete tumor regression from 0 to 11% in rectal cancer patients, from 86 to 100% in head and neck cancer patients, from 0 to 14% in the patients with soft tissue sarcomas and from 40 to 71% in children with rhabdomyosarcomas.

Management of osteogenic sarcoma patients.

The experience in the management of 246 patients with local osteogenic sarcoma and 67 patients with pulmonary metastases in the All-Union Oncologic Research Center, AMS USSR, is presented here. All the patients underwent surgery, but starting in 1974, various modalities of adjuvant chemotherapy (not randomized) were applied in addition. In the surgery alone group, prognosis was very poor: only 7.

[Survival and prognosis in adjuvant chemotherapy for osteogenic sarcoma patients].

The effect of adjuvant chemotherapy on survival and prognosis in osteogenic sarcoma versus basic clinico-roentgenomorphological characteristics of tumor was studied in 108 cases. Prognosis was found to depend on patient's age, site and size of tumor, but mainly on the roentgeno-morphological pattern of the latter. Osteolytic form appeared to have a better course in cases of adjuvant chemotherapy.

[Possibilities of endoprosthesis in osteogenic sarcoma in children].

Endoprostheses of the knee (14) and hip (after Sivash ) (2) joints were used in the treatment of 16 children operated on for osteogenic sarcoma at the Center Clinic. Postoperative complications leading to amputation occurred in two cases of lesions of the proximal part of shinbone . Good functional results were obtained: knee joints supplied with endoprosthesis flexed through 80 degrees.

[Role and place of radio- and chemotherapy in treating bone sarcomas].

The results of combination therapy of 510 patients with osteosarcoma were analysed. It was established that most advantage is offered by this therapy in cases of osteogenic sarcoma and Ewing's sarcoma supplemented with surgery whenever required. A 33.

[Current approaches to the combination therapy of osteogenic sarcoma].

The results of treatment of 315 cases of osteogenic sarcoma are presented. Available methods of primary tumor therapy fail to prevent dissemination of neoplastic disease by blood circulation. However, following a prophylactic course of chemotherapy (adriamycin, vincristine, cyclophosphamide, sarcolysine), 3- and 5-year survival rates in 45 cases of limb amputation for osteosarcoma increased to 38.