Publications by authors named "Amirah Zulkifli"
Joint Bone Spine
May 2024
Article Synopsis
- - Osteoarthritis (OA) is the most common chronic joint disease and leads to significant societal costs, but current treatments don't effectively stop or reverse the damage to cartilage, which is crucial in OA progression.
- - The loss or malfunction of chondrocytes, which are the cells responsible for maintaining cartilage, is a key factor in cartilage breakdown, and their death through a process called apoptosis contributes to this deterioration.
- - Autophagy, a cell survival mechanism that helps get rid of damaged components, could be a promising treatment target to prevent chondrocyte apoptosis and slow down OA; however, more research is needed to understand how autophagy and apoptosis are connected in these cells.
Article Synopsis
- - Tendon injuries are common and difficult to treat due to slow healing and poor tissue repair, often resulting in weakened, disorganized tissue.
- - Mesenchymal stem cell (MSC) therapy shows promise for improving tendon repair, especially when MSCs are exposed to low oxygen (hypoxic) conditions, which boosts their ability to differentiate into tendon cells.
- - The review explores how hypoxia-inducible factor-1-alpha (HIF-1α) is crucial in this process, particularly its interactions with growth factors like FGF-2 and TGF-β1, and highlights strategies to enhance HIF-1α to improve MSC therapy effectiveness.
