Plasma NT1-tau and Aβ correlate with age and cognitive function in two large Down syndrome cohorts.

Introduction: People with Down syndrome (DS) often develop Alzheimer's disease (AD). Here, we asked whether ultrasensitive plasma immunoassays for a tau N-terminal fragment (NT1-tau) and Aβ isoforms predict cognitive impairment.

Methods: Plasma NT1-tau, Aβ , Aβ , and Aβ levels were measured in a longitudinal discovery cohort (N = 85 participants, 220 samples) and a cross-sectional validation cohort (N = 239).

Plasma NT1-tau and Aβ correlate with age and cognitive function in two large Down syndrome cohorts.

Introduction: People with Down syndrome (DS) often develop Alzheimer disease (AD). Here we asked whether ultrasensitive plasma immunoassays for a tau N-terminal fragment (NT1-tau) and Aβ isoforms predict cognitive impairment.

Methods: Plasma NT1-tau, Aβ , Aβ , and Aβ levels were measured in a longitudinal discovery cohort (N = 85 participants, 220 samples) and a cross-sectional validation cohort (N = 239).