Effect of leg pedaling exercise from an inclined position on functional ability and strength in children with diplegia.

Objectives: Children with spastic diplegic cerebral palsy (SDCP) can develop various complications that affect their daily activities and quality of life, such as impaired functional ability, trunk control, and muscle weakness. This study evaluated the effects of lower extremity pedaling exercise from an inclined position on functional ability, trunk control, and muscle strength in these children.

Methods: Thirty children diagnosed with SDCP, aged 6-9 years, were randomly assigned to two groups: a study group (Group A) and a control group (Group B).

Percutaneous closure of anomalous left coronary artery from pulmonary artery rare procedure in desperate situation: case report.

Background: When anomalous left coronary artery from the pulmonary artery is diagnosed in infancy, it is associated with high mortality, but collaterals permit rare adult survival despite coronary steal. We report normalisation of perfusion abnormality after transcatheter proximal left coronary occlusion in a symptomatic adult with inducible ischaemia.

Methods: A forty-eight-year-old female presented with exertional chest pain; EKG showed sinus rhythm with left axis deviation with intraventricular conduction defect.

CX3CR1-Fractalkine Dysregulation Affects Retinal GFAP Expression, Inflammatory Gene Induction, and LPS Response in a Mouse Model of Hypoxic Retinopathy.

Diabetic retinopathy (DR) causes vision loss due to sustained inflammation and vascular damage. The vascular damage is evident by fibrinogen leakage, angiogenesis, and hypoxia. Neuronal regulation of microglia via the CX3CL1 (Fractalkine or FKN)-CX3CR1 pathway plays a significant role in retinal pathology.

Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection.

The human immunological mechanisms defining the clinical outcome of SARS-CoV-2 infection remain elusive. This knowledge gap is mostly driven by the lack of appropriate experimental platforms recapitulating human immune responses in a controlled human lung environment. Here, we report a mouse model (i.

The effect of mild hyperuricemia on urinary transforming growth factor beta and the progression of chronic kidney disease.

Although mild hyperuricemia is common in patients with renal disease, it has usually been considered a marker of reduced nephron mass rather than a risk factor for progression of kidney disease. On the other hand, experiments in a rat model demonstrated important deleterious effects of mild hyperuricemia on several aspects of renal structure and function. In the present investigation, the impact of the discontinuation of allopurinol therapy on the control of hypertension and the rate of progression of chronic kidney disease was considered.