Publications by authors named "Amira R El-Ansary"

A devasting stage of chronic hepatic dysfunction is strictly correlated with neurological impairment, signifying hepatic encephalopathy (HE). HE is a multifactorial condition; therefore, hyperammonemia, oxidative stress, neuroinflammation, and mitochondrial dysfunction interplay in HE's progressive development. Cilostazol (Cilo) has shown promising neuroprotective and hepatoprotective effectiveness in different neuronal and hepatic disorders; however, its efficiency against HE hasn't yet been explored.

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Background: Cold hydrotherapy is an ancient practice that has recently gained scientific interest for its potential health benefits. This study explored the effects of regular cold shower exposure on immune cell function.

Methods: Sixty healthy Egyptian adults were randomized to take cold or hot showers daily for 90 days.

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Article Synopsis
  • Hepatic encephalopathy (HE) is a serious condition that links liver damage to brain dysfunction, often causing oxidative stress and inflammation.
  • The study explored the protective effects of Mirabegron (Mira), a drug with antioxidant and anti-inflammatory properties, against liver and brain injuries induced by thioacetamide (TAA) in rats.
  • Results showed that Mira improved motor skills, reduced ammonia levels, and lessened liver and brain damage by promoting antioxidant defenses and reducing inflammation and cell death while activating neuroprotective pathways.
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(1) Background: Type 2 diabetes mellitus (T2DM) is one of the rapidly growing healthcare problems, and several vitamin D receptor (VDR) polymorphisms seem to modulate the risk of T2DM. Our research was designed to investigate the allelic discrimination of VDR polymorphisms and T2DM occurrence risk. (2) Methods: This case-control research included 156 patients with T2DM and 145 healthy control subjects.

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Background: Hepatitis C viral infection (HCV) and hepatocellular carcinoma (HCC) are potential health problems. New directly acting antivirals (DAAs) changed HCV treatment strategies. Selenoprotein P1 (SEPP1) is a hepatokine implicated in HCC pathogenesis.

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