Purpose: Control of Streptococcus mutans can prevent caries in high-risk preschool children. The purpose of this study was to assess the effect of casein phosphopeptide amorphous calcium phosphate (CPP-ACP) on Streptococcus mutans in the plaque of high-risk preschool children.
Methods: A triple blind, randomized, controlled clinical trial included 40 healthy three- to five-year-olds with at least one white spot lesion.