Publications by authors named "Amir Shahbaz"

The green synthesis of silver nanoparticles (AgNPs) using plant-based derivatives is getting attention for biological applications because of their small dimensions and shape. In this study, AgNPs were prepared using leaf extract of Argyrolobium roseum (A. roseum) (Camb.

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The aim of the study is to compare the outcomes among ST-segment elevation myocardial infarction (STEMI) cases with early treatment vs delayed treatment. It was a prospective comparative study on 186 patients with consecutive (nonprobability) sampling. Two groups of cases were made as per their time to get admitted to the hospital (ie, within 2 hours of symptom onset = Group A; after 2 hours of symptom onset = Group B).

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Pulmonic valve endocarditis is a rare and clinically elusive identity, commonly associated with congenital heart malformations and intravenous (IV) drug abuse. We describe a case of a 40-year-old male who has established sickle cell disease and presented with pain crisis, febrile episodes, and oxygen desaturation on room air. The clinical presentation and echocardiographic findings of a pulmonic mass were consistent with the diagnosis of pulmonic valve endocarditis.

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Article Synopsis
  • The FDA has approved TAVR as a treatment for patients with symptomatic aortic valve stenosis, particularly those at high risk for surgery.
  • Recent guidelines suggest that patients with bio-prosthetic AV stenosis should consider repeat valve replacement, but there's limited support for urgent TAVR in unstable patients.
  • A unique case is presented where emergency TAVR was successfully performed on a hemodynamically unstable patient with severe symptomatic bio-prosthetic AV stenosis.
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Phytochemicals are directly involved in therapeutic treatment or precursors to synthesize useful drugs. The current study was aimed to evaluate the phytocompounds and their biopotentials using methanolic and n-hexane extracts of various parts of . For the phytochemical analysis, standard procedures were used, whereas Aluminum Chloride reagent and Follin-ciocalteau reagent methods were used to determine total flavonoid and phenolic contents.

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In the recent years, green synthesis of zinc oxide nanoparticles (ZnONPs) using plant extracts and phytochemicals has gained significant attention. In present research study, facile, green, and tunable ZnONPs were biosynthesized from Rhamnella gilgitica leaf aqueous extract as a strong reducing and stabilizing agents. The prepared ZnONPs@Rhamnella were characterized and validated using common nanotechnology techniques (UV-Vis, XRD, EDX, FT-IR, SEM, TEM, DLS, and Raman) and revealed spherical morphology with particle size ~21 nm.

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Present study established the biological potential of , and extracts for their potential applications in drug formulations. Initially, FTIR was performed to ascertain functional groups and then plant extracts were prepared using five solvents depending on the polarity. Total phenolic contents were observed in the range of 36.

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Medicinal plants largely serve as a source of bioactive compounds in traditional medicines to cure various diseases. The present study was aimed at chemical composition, antioxidant, antimicrobial, cytotoxic and antihemolytic potential of five different extracts of G. hispida and (Boraginaceae).

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Article Synopsis
  • The study focuses on the production of zinc oxide nanoparticles (ZnONPs) using leaf extracts from Elaeagnus angustifolia (EA), which provides a non-toxic method for synthesis.
  • Various analytical techniques confirmed the physical and chemical properties of the ZnONPs, revealing their nanoscale size and potential for various applications.
  • The ZnONPs demonstrated promising anticancer and antimicrobial activities, as well as strong antioxidant properties, indicating their potential for clinical development.
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Epipericardial fat necrosis (EFN) is an inflammatory process that occurs in the mediastinal fat surrounding the heart. It is a rare cause of acute chest pain and mimics more ominous clinical conditions such as acute coronary syndrome, aortic dissection, and pulmonary embolism. Clinicians are often not familiar with this condition due to its infrequent occurrence, and traditional textbooks of medicine and cardiology have not covered this topic adequately.

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Article Synopsis
  • Sophora alopecuroides L. (SA) is identified as a medicinal plant, and the study focuses on examining the phytochemical, pharmacological properties, and physical characteristics of its seeds.
  • Various extraction methods were used, revealing significant antioxidant, antidiabetic, anti-leishmanial, antibacterial, and antifungal activities, particularly in methanol extracts, which contained high levels of phenolics and flavonoids.
  • The study concludes that SA seeds exhibit considerable medicinal potential and suggests further research to explore their bioactive compounds and conduct in vivo toxicity assessments.
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The tunable cobalt oxide nanoparticles (CoONPs) are produced due to the phytochemicals present in Rhamnus virgata (RhV) leaf extract which functions as reducing and stabilization agents. The synthesis of CoONPs was confirmed using different analytical techniques: UV-Vis spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), dynamics light scatterings (DLS), Fourier-transform infrared spectroscopy (FTIR), energy dispersive X-ray, and Raman spectroscopy analyses. Furthermore, multiple biological activities were performed.

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Atypical hemolytic uremic syndrome (aHUS), defines as non-Shiga toxin HUS, is thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, consumptive thrombocytopenia, and renal impairment. aHUS is associated with high morbidity and mortality, necessitating the need for an early diagnosis to limit target organ damage. Mutations or autoantibodies against specific complement factors over-activate the complement system forming microthrombi.

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In the present study, green silver nanoparticles (Ag ONPs) were prepared from aqueous and ethanolic leaves extract of Rhamnus virgata in a facile, green, cost-effective, and eco-friendly way. The color changes from light brown to brownish black determined the synthesis of Ag ONPs and Ag ONPs . The phytofabrication of Ag ONPs was confirmed using various spectroscopic and microscopic techniques: energy-dispersive X-ray spectroscopy, dynamic light scattering, ultraviolet-visible spectroscopy, Fourier-transform infrared, X-ray powder diffraction, Raman, scanning electron microscopy, and transmission electron microscopy.

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Article Synopsis
  • Nickel oxide nanoparticles (NiONPs) are typically problematic due to their toxic byproducts, but a new green chemistry method using fresh leaf broth (RT) offers a non-toxic alternative for their synthesis.
  • The resulting RT-NiONPs showed promising properties confirmed by various analytical techniques, including UV-Vis and SEM, and displayed notable biological activities such as anticancer effects against liver cancer cell lines.
  • The study suggests that RT-NiONPs are biocompatible and have potential antimicrobial and antioxidant properties, highlighting the need for further in vivo research to explore their applications in treating chronic diseases.
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Hereditary multiple osteochondromas (HMO) is an autosomal dominant disease diagnosed by the presence of two or more than two osteochondromas on radiographs. The majority of cases are asymptomatic. The presence of bony growth, pain, and compression of the surrounding structure are the usual presentations.

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Domperidone is a dopamine-2 receptor (D2) antagonist. It is used as an antiemetic and has an excellent safety profile. We present a case of acute dystonia secondary to domperidone use in an 11-year-old girl.

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Synthetic cannabinoid abuse can manifest with an array of unpredictable reactions ranging from sedation to hallucinations, psychosis, and seizures. Acute liver injury associated with the synthetic cannabinoid use is a rare complication. We present a case of a 22-year-old homeless male presented with abdominal pain and vomiting.

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There is an increased association between chronic urticaria (CU) and thyroid autoantibodies. We presented a case of a patient suffering from CU and newly diagnosed Hashimoto's thyroiditis in which levothyroxine therapy completely resolved the symptoms of urticaria. A 58-year-old female with a past medical history of recurrent urticaria presented with complaints of fatigue and weight gain.

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Macroglossia is an uncommon condition that causes cosmetic and functional disabilities. We present a case of a 67-year-old patient with the past medical history of vitamin B12 deficiencies who presented with macroglossia and was found to have amyloidosis. She had an enlarged tongue with multiple ulcerations secondary to traumatic injury from dentation along with difficulty swallowing.

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Dermatomyositis and thrombotic thrombocytopenic purpura (TTP) are both rare diseases. TTP is a blood abnormality in which blood clots form in blood vessels leading to fatal outcomes. Dermatomyositis is an inflammatory myopathy which causes a distinctive skin rash and muscle weakness.

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Extra-adrenal pheochromocytoma is uncommon and usually secreting nor-epinephrine. We are presenting a possible case of extra-adrenal pheochromocytoma in a 68-year-old male who was admitted to Queens Hospital Center complaining of shortness of breath for two days. Physical examination was unremarkable except tachycardia.

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