Publications by authors named "Amir Saab"
Background: Parvovirus B19 infection has been associated with various clinical entities including musculoskeletal manifestations and the development of different autoimmune diseases. The aim of our study is to examine the musculoskeletal manifestations associated with acute parvovirus B19 infection and the possible development of chronic autoimmune rheumatic diseases.
Patients And Methods: Retrospective cohort study that included adult hospitalized patients diagnosed with an acute parvovirus B19 infection between 1 January 2021 and 1 February 2024.
Cognitive impairment is frequently reported among anti-phospholipid syndrome (APS) patients as well as anti-phospholipid antibody (aPL) carriers, but it is less studied than other manifestations of this condition. Moreover, the exact prevalence of cognitive impairment in these patients has not been accurately determined, mainly due to inconsistency in the tools used to identify impairment, small sample sizes, and variability in the anti-phospholipid antibodies measured and positivity cutoffs. The notion of a direct pathogenic effect is supported by the observation that the higher the number of aPLs present and the higher the load of the specific antibody, the greater the risk of cognitive impairment.
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- The study investigates the lack of head-to-head trials comparing different biologic disease-modifying antirheumatic drugs (bDMARDs) for treating rheumatoid arthritis (RA), making the choice largely dependent on rheumatologists' preferences.
- Researchers conducted a retrospective analysis of 4,268 RA patients from 2000-2017, finding that only 19.2% received bDMARDs, with infliximab showing the longest average drug survival of 47.1 months, while golimumab had the shortest at 14.9 months.
- Key factors linked to longer drug survival included being male, using concurrent conventional DMARDs, and starting bDMARD therapy in earlier calendar years.*
We report the case of 19-year-old woman with severe hypercalcemia who was evaluated with a bone scan to exclude bone metastases. Increased uptake in both lungs was detected on the bone scan. The patient's final diagnosis was systemic lupus erythematous (SLE).
View Article and Find Full Text PDFBackground: Peripheral neuropathy is considered a common complication in patients suffering from advanced chronic kidney disease (CKD). Superimposed peripheral multiple neuropathies may complicate arteriovenous (A-V) fistulas construction.
Aim: To evaluate, prospectively, the influence of brachiocephalic A-V fistulas construction on the peripheral nerves of the same extremity and to characterize the patients at risk for developing ischemic and neurological complications.