Publications by authors named "Amir Reza Ameri"

Article Synopsis
  • - The study presents a two-phase approach to develop and characterize novel hybrid nano-photosensitizers for targeting breast cancer, integrating molecular simulations with laboratory and animal experiments for improved model accuracy.
  • - In the first phase, researchers used artificial intelligence and molecular docking to identify pharmacokinetic weaknesses and synthesized biohybrid nanoplatforms, assessing their stability in vivo.
  • - The second phase optimized photodynamic treatment variables and demonstrated that the optimized nano-photosensitizer effectively killed triple-negative cancer cells in both static and dynamic cultures, indicating a promising strategy for enhancing cancer treatment.
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Introduction: Protoporphyrin-IX (PpIX), a photosensitizer used in photodynamic therapy, has limitations due to its hydrophobicity, rapid photobleaching, and low absorption peak in the red region. These limitations make the use of PpIX less effective for photodynamic therapy treatments. In this study, we harnessed the power of microfluidic technology to manipulate the properties of PpIX and quickly synthesize albumin-based hybrid nanoshells with high reproducibility.

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There is a growing interest in developing microfluidic biosensors for the accurate and reproducible analysis of various biomarkers obtained from liquid biopsy. This paper reports a novel microfluidic electrochemical aptasensor for determination of A549 cells as integrin α6β4-containing cell model and circulating tumor cell (CTC) model of NSCLC, based on target-induced structure switching mode. The conformational change of IDA aptamer structure with an affinity towards A549 cells, in the absence and presence of A549 cells allowed selective and sensitive detection of A549 cells.

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Microfluidics provides enabling platforms for various cell culture, drug testing and synthesis of drug carriers using chip-based microsystems. In this study, we present a novel integrated whole-thermoplastic microfluidic chip to provide a platform for on-chip cell culture at static and dynamic conditions. The whole chip was made of polymethyl methacrylate (PMMA) and thermoplastic polyurethane (TPU) using high precision micromilling and laser micromachining, assembled by thermal fusion bonding.

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