Disease response in rheumatoid arthritis across four biologic therapies associates with improvement in paraoxonase-1 activity and oxylipins.

Objective: Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme, that has been implicated as a biomarker of cardiovascular risk in patients with rheumatoid arthritis (RA). We aimed to investigate how different biologic therapies affect levels of PON1 and oxylipins.

Methods: 1213 adult patients with RA in the Comparative Effectiveness Registry to study Therapies for Arthritis and Inflammatory CoNditions cohort study with moderate-to-high disease activity (Clinical Disease Activity Index (CDAI) >10) who initiated a new biologic (tocilizumab (TCZ), n=296; abatacept, n=374; tumour necrosis factor inhibitors, n=427; rituximab, n=116) were followed prospectively with serum specimens analysed for PON1 activity by arylesterase (ARYL), lactonase (LAC) and PON assays at baseline and after 6 months of biologic therapy.

Microplastics and dye removal from textile wastewater using MIL-53 (Fe) metal-organic framework-based ultrafiltration membranes.

Microplastics (MPs) and other organic matters in textile wastewater have posed a formidable challenge for treatment processes, particularly in the primary stages such as ultrafiltration (UF). UF plays a crucial role in preventing the entry of pollutants into subsequent treatment steps. However, the performance efficiency of UF membranes is compromised by the potential fouling of membrane pores by MPs, dyes and other organic pollutants such as bovine serum albumin (BSA).

Dual modification of reverse osmosis membranes with NH-MIL-125 and functionalised multiwalled carbon nanotubes for enhanced nanoplastic removal.

The present study describes a novel double-modified strategy for developing high-performance thin-film composite reverse osmosis (TFC-RO) membranes by incorporating titanium-based metal organic frameworks (NH-MIL-125) and functionalised multiwalled carbon nanotubes (MWCNTs) into the support layer and selective layer, respectively. Initially, the support layer was subjected to successive modifications using NH-MIL-125 mixed with polysulfone (PSF) in dimethylformamide DMF solution to investigate their impact on the performance and properties of the support layer and resultant TFC-RO membranes. Results indicated that the new structure of the modified support layer had significant influences on the developed TFC-RO membranes.

Surface Modification of Polystyrene with Boronic Acid for Immunoaffinity-Based Cell Enrichment.

Obtaining an enriched and phenotypically pure cell population from heterogeneous cell mixtures is important for diagnostics and biosensing. Existing techniques such as fluorescent-activated cell sorting (FACS) and magnetic-activated cell sorting (MACS) require preincubation with antibodies (Ab) and specialized equipment. Cell immunopanning removes the need for preincubation and can be done with no specialized equipment.

Enhancing Water Safety: Exploring Recent Technological Approaches for Drowning Detection.

Drowning poses a significant threat, resulting in unexpected injuries and fatalities. To promote water sports activities, it is crucial to develop surveillance systems that enhance safety around pools and waterways. This paper presents an overview of recent advancements in drowning detection, with a specific focus on image processing and sensor-based methods.

Recent advances in surface tailoring of thin film forward osmosis membranes: A review.

The recent advancements in fabricating forward osmosis (FO) membranes have shown promising results in desalination and water treatment. Different methods have been applied to improve FO performance, such as using mixed or new draw solutions, enhancing the recovery of draw solutions, membrane modification, and developing FO-hybrid systems. However, reliable methods to address the current issues, including reverse salt flux, fouling, and antibacterial activities, are still in progress.

Meniere's disease: Pathogenesis, treatments, and emerging approaches for an idiopathic bioenvironmental disorder.

Meniere's disease (MD) is a severe inner ear condition known by debilitating symptoms, including spontaneous vertigo, fluctuating and progressive hearing loss, tinnitus, and aural fullness or pressure within the affected ear. Prosper Meniere first described the origins of MD in the 1860s, but its underlying mechanisms remain largely elusive today. Nevertheless, researchers have identified a key histopathological feature called Endolymphatic Hydrops (ELH), which refers to the excessive buildup of endolymph fluid in the membranous labyrinth of the inner ear.

In vivo evaluation of bone regeneration using ZIF8-modified polypropylene membrane in rat calvarium defects.

Aim: The profound potential of zeolitic imidazolate framework 8 (ZIF8) thin film for inducing osteogenesis has been previously established under in vitro conditions. As the next step towards the clinical application of ZIF8-modified substrates in periodontology, this in vivo study aimed to evaluate the ability of the ZIF8 crystalline layer to induce bone regeneration in an animal model defect.

Materials And Methods: Following the mechanical characterization of the membranes and analysing the in vitro degradation of the ZIF8 layer, in vivo bone regeneration was evaluated in a critical-sized (5-mm) rat calvarial bone defect model.

Bioinspired Angstrom-Scale Heterogeneous MOF-on-MOF Membrane for Osmotic Energy Harvesting.

Membrane-based salinity gradient energy generation from the osmotic potential at the interface of a river and seawater through reverse electrodialysis is a promising route for realizing clean, abundant, and sustainable energy. Membrane permeability and selective ion transport are crucial for efficient osmotic energy harvesting. However, balancing these two parameters in the membrane design and synthesis remains challenging.

Recent Advances In the development of enzymatic paper-based microfluidic biosensors.

Using microfluidic paper-based analytical devices has attracted considerable attention in recent years. This is mainly due to their low cost, availability, portability, simple design, high selectivity, and sensitivity. Owing to their specific substrates and catalytic functions, enzymes are the most commonly used bioactive agents in μPADs.

Materials discovery of ion-selective membranes using artificial intelligence.

Significant attempts have been made to improve the production of ion-selective membranes (ISMs) with higher efficiency and lower prices, while the traditional methods have drawbacks of limitations, high cost of experiments, and time-consuming computations. One of the best approaches to remove the experimental limitations is artificial intelligence (AI). This review discusses the role of AI in materials discovery and ISMs engineering.

Electrospun nanofiber composite membranes for geothermal brine treatment with lithium enrichment via membrane distillation.

In this study, a composite electrospun nanofiber membrane was fabricated and used to treat a geothermal brine source with lithium enrichment. An in-situ growth technique was applied to incorporate silica nanoparticles on the surface of nanofibers with (3-Aminopropyl) triethoxysilane as the nucleation site. The fabricated composite nanofiber membrane was heat pressed to enhance the integration of the membrane and its mechanical stability.

Mechanism Understanding of Li-ion Separation Using A Perovskite-Based Membrane.

Lithium ions play a crucial role in the energy storage industry. Finding suitable lithium-ion-conductive membranes is one of the important issues of energy storage studies. Hence, a perovskite-based membrane, Lithium Lanthanum Titanate (LLTO), was innovatively implemented in the presence and absence of solvents to precisely understand the mechanism of lithium ion separation.

A juxtaposed review on adsorptive removal of PFAS by metal-organic frameworks (MOFs) with carbon-based materials, ion exchange resins, and polymer adsorbents.

The removal of poly- and perfluoroalkyl substances (PFAS) from the aquatic environment is a universal concern due to the adverse effects of these substances on both the environment and public health. Different adsorbents, including carbon-based materials, ion exchange resins, biomaterials, and polymers, have been used for the removal of short-chain (C < 6) and long-chain (C > 7) PFAS from water with varying performance. Metal-organic frameworks (MOFs), as a new generation of adsorbents, have also been recently used to remove PFAS from water.

Synergistic effects of microplastics and organic foulants on the performance of forward osmosis membranes.

Microplastics (MPs) are emerging contaminants that are abundantly present in the influent and effluent of wastewater treatment plants (WWTPs). Forward osmosis (FO) is an advanced treatment technology with potential applications in WWTPs. The presence of MPs in WWTP effluents can contribute to FO fouling and performance deterioration.

Suppressed paraoxonase-1 activity associates with elevated oxylipins and the presence of small airways disease in patients with rheumatoid arthritis.

Background: Rheumatoid arthritis (RA)-associated lung disease (LD) associates with significantly increased morbidity and mortality. Although oxidative stress plays an important role in the inflammatory responses in other forms of lung disease, minimal work has evaluated its role in RA-LD. The current work examines the relationship between the anti-oxidant HDL-associated enzyme paraoxonase-1 (PON1), the PON1 Q192R polymorphism, and a targeted oxylipin panel with RA-LD.

XGBoost model as an efficient machine learning approach for PFAS removal: Effects of material characteristics and operation conditions.

Due to the implications of poly- and perfluoroalkyl substances (PFAS) on the environment and public health, great attention has been recently made to finding innovative materials and methods for PFAS removal. In this work, PFAS is considered universal contamination which can be found in many wastewater streams. Conventional materials and processes used to remove and degrade PFAS do not have enough competence to address the issue particularly when it comes to eliminating short-chain PFAS.

High durability of food due to the flow cytometry proved antibacterial and antifouling properties of TiO decorated nanocomposite films.

Although polymeric membrane has superior properties, its applications in biomedical and food industrial fields are minimal. Biofouling is a significant concern in the membrane, created from particular interactions between the membrane and untreated water content. This research showed that a careful superhydrophilic modification of polyethersulfone membrane could address those drawbacks that have hindered their utility.

Recent advancements in bioelectronic devices to interface with the peripheral vestibular system.

Balance disorders affect approximately 30% of the population throughout their lives and result in debilitating symptoms, such as spontaneous vertigo, nystagmus, and oscillopsia. The main cause of balance disorders is peripheral vestibular dysfunction, which may occur as a result of hair cell loss, neural dysfunction, or mechanical (and morphological) abnormality. The most common cause of vestibular dysfunction is arguably vestibular hair cell damage, which can result from an array of factors, such as ototoxicity, trauma, genetics, and ageing.

Electro-Driven Materials and Processes for Lithium Recovery-A Review.

The mass production of lithium-ion batteries and lithium-rich e-products that are required for electric vehicles, energy storage devices, and cloud-connected electronics is driving an unprecedented demand for lithium resources. Current lithium production technologies, in which extraction and purification are typically achieved by hydrometallurgical routes, possess strong environmental impact but are also energy-intensive and require extensive operational capabilities. The emergence of selective membrane materials and associated electro-processes offers an avenue to reduce these energy and cost penalties and create more sustainable lithium production approaches.

A Smart Multi-Sensor Device to Detect Distress in Swimmers.

Drowning is considered amongst the top 10 causes of unintentional death, according to the World Health Organization (WHO). Therefore, anti-drowning systems that can save lives by preventing and detecting drowning are much needed. This paper proposes a robust and waterproof sensor-based device to detect distress in swimmers at varying depths and different types of water environments.

Rare Earth Elements Recovery Using Selective Membranes via Extraction and Rejection.

Recently, demands for raw materials like rare earth elements (REEs) have increased considerably due to their high potential applications in modern industry. Additionally, REEs' similar chemical and physical properties caused their separation to be difficult. Numerous strategies for REEs separation such as precipitation, adsorption and solvent extraction have been applied.

High-Sensitivity 3D ZIF-8/PDA Photonic Crystal-Based Biosensor for Blood Component Recognition.

Optical biosensors are sensitive devices used in bioanalytics detection. Analysis of blood constituents is very important for the detection of major diseases and also performs a significant role in the diagnosis of diabetes, various cancers, and cardiovascular disorders. In this work, a three-dimensional photonic crystal-based biosensor composed of zeolitic imidazolate framework-8 (ZIF-8) nanoarrays are placed on polydopamine (PDA) coated on a silicon substrate.

Mechanobiology of Dental Pulp Stem Cells at the Interface of Aqueous-Based Fabricated ZIF8 Thin Film.

The limited knowledge on how biological systems sense and respond to the mechanical properties of metal-organic framework (MOF) thin films is a critical restriction factor for their extensive usage. To bridge this gap, we performed an study for defining and linking surface characteristics at the interface of the zeolitic imidazolate framework-8 (ZIF8) thin layer to stem cell behavior. First, the physio-mechanical properties of the ZIF8 layer grown on polydopamine (PDA) and tannic acid (TA) layers have been studied.