Publications by authors named "Amir R Pashmineh Azar"
Polyethylene glycol-asparaginase (PEGAsp) is an established component of acute leukemia therapy. Hypersensitivity reactions to PEGAsp occur in 10% to 15% of patients, with polyethylene glycol suggested as the antigenic culprit. As coronavirus disease 2019 (COVID-19) mRNA vaccines contain polyethylene glycol, the safety of administration of these vaccines to patients with prior PEGAsp hypersensitivity has been questioned.
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- The study aimed to improve the prediction of viable CD34+ hematopoietic progenitor cells (HPCs) for better engraftment in transplants, using a machine-learning model based on data collected on the day of apheresis.
- A retrospective review of 370 autologous HPC collections highlighted that 17% of products had a "poor" post-thaw index, with the XGBoost model showing the highest accuracy in predicting these losses.
- The findings indicated that considering post-thaw vCD34% improved engraftment times without necessitating extra collection days, suggesting a significant reduction in unnecessary procedures could be achieved with better predictive methods.
Rise and regional disparities in buprenorphine utilization in the United States.
Pharmacoepidemiol Drug Saf
June 2020
Purpose: Buprenorphine is an opioid partial agonist used to treat opioid use disorder. While several policy changes have attempted to increase buprenorphine availability, access remains well below optimal levels. This study characterized how buprenorphine utilization in the United States has changed over time and whether there are regional disparities in distribution of the medication.
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