Publications by authors named "Amir Peled"
Objective: Obesity and overweight are associated with an increased risk for cardiovascular disease. Since fat mass (FM) and fat-free mass (FFM) both contribute to total body weight (TBW), we characterized the post-heart transplantation (HT) change in TBW and its implications for outcomes.
Methods: Post-HT changes in TBW, FM, and FFM were reviewed for 211 HT patients assessed during 1997-2017.
Article Synopsis
- The study investigates how thyroid hormone therapy in heart donors affects primary graft dysfunction (PGD) in transplant recipients, with a focus on data from 209 heart transplantation cases between 1997 and 2018.
- Results show that recipients from donors who received T4 therapy had significantly higher rates (58% vs 35%) and severity of PGD compared to those whose donors did not receive the therapy.
- The study concludes that donor thyroid hormone therapy increases the risk of PGD, suggesting that administering thyroid hormone to recipients during reperfusion might reduce this risk, warranting further prospective research.
Article Synopsis
- The study examined the impact of early recurrent grade 1R rejections on long-term results after heart transplants, focusing on grades 1A versus 1B/2.
- It involved analyzing data from heart transplant patients between 1992 and 2017, specifically looking at those with multiple early rejections within three months.
- Findings showed that early recurrent 1R rejections are linked to a higher risk of later rejections, worse survival rates, and increased cardiovascular mortality, with severity differing between patients classified as 1B/2 and those as 1A.
Article Synopsis
- The study investigates the impact of early aspirin therapy on the long-term risk of cardiac allograft vasculopathy (CAV) in heart transplant patients.
- It analyzes data from 206 patients who underwent heart transplantation between 1991 and 2016, using statistical modeling to compare outcomes.
- The results show that patients who received early aspirin treatment had a significantly lower risk of developing CAV and related mortality after 15 years compared to those who did not receive the treatment.
Article Synopsis
- The study investigates changes in rejection risk for heart transplant patients over 25 years, linking trends to advancements in medical management.
- It analyzed data from 216 patients, dividing rejection periods into early, intermediate, and late categories, and comparing treatment eras from 1991-1999 and 2000-2016.
- Results showed a significant decrease in major rejection rates for more recent patients, indicating that while new medications were considered, other factors also contributed to improved outcomes in heart transplant recipients.
Metformin therapy reduces the risk of malignancy after heart transplantation.
J Heart Lung Transplant
December 2017
Article Synopsis
- The study explored the link between metformin, a common anti-diabetic drug, and the risk of developing cancer post-heart transplantation (HTx) in patients with diabetes mellitus (DM).
- Among 237 heart transplant patients, those with DM who were treated with metformin showed a significantly lower malignancy rate (4%) compared to those not on metformin (62%) and non-DM patients (27%) after 15 years.
- The results indicate that metformin therapy is associated with a 90% reduction in the risk of cancer for DM patients, suggesting its potential protective role after HTx.
Aims: There are limited data on the effect of low-dose, intermittent inotropic therapy in an outpatient setting on the quality of life (QOL) in patients with advanced refractory heart failure (HF) symptoms. We aimed to analyse the effect of this treatment modality on QOL and subsequent survival.
Methods And Results: The study population comprised 287 consecutive patients with advanced refractory HF symptoms who were treated with low-dose, intravenous intermittent inotropic therapy in the HF Day Care Service at Sheba Medical Centre between September 2000 and September 2012.
Introduction: Hypoxia is known to reduce performance. Adaptation is limited and requires special conditions. Heat and hypoxia have been shown to share some adaptive mechanisms.
View Article and Find Full Text PDFThe current study examines the use of hand immersion in cold water to alleviate physiological strain caused by exercising in a hot climate while wearing NBC protective garments. Seventeen heat acclimated subjects wearing a semi-permeable NBC protective garment and a light bulletproof vest were exposed to a 125 min exercise-heat stress (35 degrees C, 50% RH; 5 km/h, 5% incline). The heat stress exposure routine included 5 min rest in the chamber followed by two 50:10 min work-rest cycles.
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