Publications by authors named "Amir Motamedi"
Article Synopsis
- The study investigates the relationship between postprandial hyperinsulinaemia and non-alcoholic fatty liver disease (NAFLD), suggesting that diet may affect serum insulin levels.
- A total of 3,158 participants from Tehran were assessed to determine the prevalence of NAFLD, which was found to be 29.9%, with varying rates between males and females.
- Results indicated that higher dietary insulin index (DII) was significantly linked to increased NAFLD risk for both sexes, while dietary insulin load (DIL) only showed a strong connection in females, highlighting the need for dietary considerations in NAFLD prevention.
Ghobadi and Jafari have mentioned some points about our article titled "Diet quality in relation to the risk of hypertension among Iranian adults: cross-sectional analysis of Fasa PERSIAN cohort study" which was published in the Nutrition Journal. Thanks for their consideration, the following is provided as a response to their comments.
View Article and Find Full Text PDFBackground And Objective: Almond consumption has an inverse relationship with obesity and factors related to metabolic syndrome. However, the results of available clinical trials are inconsistent. Therefore, we analyzed the results of 37 randomized controlled trials (RCTs) and evaluated the association of almond consumption with subjective appetite scores and body compositions.
View Article and Find Full Text PDFBackground And Aims: Epidemiologic studies show a strong association between chronic inflammation and type 2 diabetes (T2D). Diet may also affect the risk of T2D by modulating inflammation. This meta-analysis aimed to assess the relation of dietary inflammatory index (DII) and risk of T2D.
View Article and Find Full Text PDFBackground: Hypertension is a common chronic disease with various complications and is a main contributing factor to cardiovascular disease (CVD). This study aimed to assess the association of diet quality, assessed by dietary diversity score (DDS), Mediterranean dietary score (MDS), diet quality index-international (DQI-I), and healthy eating index-2015 (HEI-2015) with the risk of hypertension.
Methods: This study recruited a total of 10,111 individuals (45.
Article Synopsis
- Identifying cis-regulatory elements is key to understanding cellular diversity, but analyzing primary tissues is complicated by sample variability.
- Single-cell ATAC-seq (scATAC-seq) helps address this by analyzing open chromatin at the single-cell level, though it introduces computational challenges due to data noise and volume.
- SnapATAC is a new software tool designed to analyze scATAC-seq data efficiently, allowing for unbiased exploration of cellular diversity and identification of around 370,000 regulatory elements across 31 cell types in the mouse brain.
The mechanisms by which JAK2 is activated by the prevalent pseudokinase (JH2) V617F mutation in blood cancers remain elusive. Via structure-guided mutagenesis and transcriptional and functional assays, we identify a community of residues from the JH2 helix αC, SH2-JH2 linker and JH1 kinase domain that mediate V617F-induced activation. This circuit is broken by altering the charge of residues along the solvent-exposed face of the JH2 αC, which is predicted to interact with the SH2-JH2 linker and JH1.
View Article and Find Full Text PDFAurora kinases are essential for cell division and are frequently misregulated in human cancers. Based on their potential as cancer therapeutics, a plethora of small molecule Aurora kinase inhibitors have been developed, with a subset having been adopted as tools in cell biology. Here, we fill a gap in the characterization of Aurora kinase inhibitors by using biochemical and cell-based assays to systematically profile a panel of 10 commercially available compounds with reported selectivity for Aurora A (MLN8054, MLN8237, MK-5108, MK-8745, Genentech Aurora Inhibitor 1), Aurora B (Hesperadin, ZM447439, AZD1152-HQPA, GSK1070916), or Aurora A/B (VX-680).
View Article and Find Full Text PDFCentrioles are ancient organelles that build centrosomes, the major microtubule-organizing centers of animal cells. Extra centrosomes are a common feature of cancer cells. To investigate the importance of centrosomes in the proliferation of normal and cancer cells, we developed centrinone, a reversible inhibitor of Polo-like kinase 4 (Plk4), a serine-threonine protein kinase that initiates centriole assembly.
View Article and Find Full Text PDFObjective: To evaluate, in a well-controlled study, the effect of surgically induced partial bladder outlet obstruction (PBOO) on male erectile function in a rat model.
Materials And Methods: PBOO was created in 17 adult male Sprague-Dawley rats by partial ligation of the proximal urethra. Sham-operated and PBOO rats were evaluated for urodynamic and erectile function at 4-8 weeks after surgery.