Publications by authors named "Amir Mahdi Emam Jome Shahidi"

Article Synopsis
  • Cell replacement therapy (CRT) shows promise in treating neurodegenerative conditions like cerebellar ataxia (CA), with human olfactory epithelium mesenchymal stem cells (OE-MSCs) being highlighted for their immunomodulatory benefits and accessibility.
  • The study involved obtaining OE-MSCs from volunteers and testing their effects in a rat model of CA, with rats receiving treatment either with 3-AP or 3-AP followed by OE-MSC implantation.
  • Results indicated that OE-MSCs improved motor coordination and protected cerebellar cells from damage caused by 3-AP, suggesting a potential therapeutic role for OE-MSCs in managing symptoms of CA.
View Article and Find Full Text PDF

Huntington's disease (HD) is an inherited neurodegenerative disorder which begins in the striatum and then spreads to other neural areas. Known as a progressive movement cognitive disorder, HD has no efficient therapy. Although the exact mechanism of HD is still unknown, several different etiological processes such as oxidative stress have been shown to play critical roles.

View Article and Find Full Text PDF