One of the most important advantages and applications of coated nanoparticles in biological applications is their use in isolating different types of cells to diagnose and treat all types of diseases. Therefore, in this research work, the possibility of isolation and enrichment of B cells using magnetic iron oxide nanoparticles have been investigated. In this regard, magnetic nanoparticles are first coated with (3-aminopropyl)triethoxysilane to make them hydrophilic and prevent their clumping, then reacted with and rendered biocompatible by FITC anti-human CD20 antibody.
View Article and Find Full Text PDFPurpose: The cyclic AMP response element-binding protein (CREB) and nerve growth factor (NGF) have been proposed as key modulators of brain health and are involved in synaptic plasticity. The study investigates how combined water-based training affects hippocampal neuron plasticity and memory function in old rats.
Methods: 16 Wistar male rats 24-month-old were randomly divided into two groups: combined training (n = 8) and control (n = 8).
This study aimed to investigate changes in protein signaling associated with muscle regeneration in aged rats with obesity and diabetes following high-intensity interval training (HIIT) and SP supplementation. Forty male Wistar rats weighting 280-325 g were used in this study. Obesity was induced by eight weeks of a high-fat diet, and diabetes was induced by intraperitoneal injection of 40 mg/kg streptozocin.
View Article and Find Full Text PDFBackground: This study aimed to investigate the effects of different volumes of aerobic training (AT) and resistance training (RT) during a concurrent exercise training program on selected indicators of physical fitness and pulmonary function in women with spinal cord injury (SCI).
Methods: Twenty-three inactive females with complete or incomplete SCI from T6 to L5 were divided into three groups: concurrent training with a focus on AT (CTAT; two weekly sessions of AT and one of RT), concurrent training with a focus on RT (CTRT; two weekly sessions of RT and one of AT), and control (CON). Tests were performed before and after an 8-week experimental period for indicators of pulmonary function, aerobic power, endurance performance, muscular strength and endurance, speed, and change of direction.
Clin Hemorheol Microcirc
August 2024
Objectives: The purpose of this study was to investigate the effects of 6 weeks of resistance training (RT) combined with aerobic training (AT) and Tirzepatide supplementation on lipid profiles, insulin resistance, anthropometric characteristics and physical fitness in prediabetic obese soldiers.
Methods: 61 obese men were randomly divided into six groups: Placebo; Tirzepatide 5 mg (T5); Tirzepatide 2.5 mg (T2.
Gold nanoparticles (Au NPs) with graphene oxide (GO) shell (Au@GO), silver nanoparticles (Ag NPs) with GO shell (Ag@GO), and gold silver nanoparticles (AuAgNPs) with GO shell (AuAg@GO) were synthesized employing a cationic surfactant. The prepared core@shell structures were used for in situ synthesis of long tubular polyaniline structures employing cetyl trimethyl ammonium bromide (CTAB) as a soft template. This process led to a notable enhancement in the tubular nanostructure of PANI, extending its length beyond 10 μm, in the case of using core/shell Au@GO, Ag@GO, and AuAg@GO structures.
View Article and Find Full Text PDFMethamphetamine (MA) abuse is related to risks to the cardiovascular system. The present study aimed to compare the effects of moderate-intensity aerobic training (MIAT) and vitamin E (Vit.E) supplementation on markers of cardiac apoptosis following MA exposure.
View Article and Find Full Text PDFBackground: This study aimed to examine the effects of 12 weeks of resistance training (RT) and vitamin D (VitD) supplementation on muscle strength and C-terminal agrin fragment (CAF) and Neurotrophin-3 (NT-3) concentrations as potential biomarkers in postmenopausal women.
Methods: This was a randomized double-blind placebo-controlled study. Forty-four healthy postmenopausal women (55.
Unlabelled: In Alzheimer's disease (AD) patients, low levels of physical fitness (PF) and cognitive status are associated with high rates of depression. However, this condition can be improved through physical training.
Objective: The aim of the present study was to investigate the effect of multimodal exercise training (MET) on aerobic endurance, muscular strength, agility, dynamic balance, cognitive status, and depressive symptoms in men with mild-to-moderate AD.
The present study aimed to investigate the effects of 8-week of coenzyme Q10 (CoQ10) supplementation alone or combined with concurrent training (CT) on functional capacity, serum brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in multiple sclerosis (MS) patients. Our hypothesis is that CT promotes improvements in the studied outcomes with higher results for the combination of CT and CoQ10. Randomized placebo-controlled trial.
View Article and Find Full Text PDFObjectives: One of the consequences of old age is cognitive and physical decline, which can cause a wide range of problems. These complications are more pronounced in those with type 2 diabetes (T2D). The aim of this pilot study was to investigate the effect of combined exercise training on blood biomarkers, physical fitness, and cognitive function in elderly women with T2D.
View Article and Find Full Text PDFBackground: Coronavirus disease 2019 (COVID-19) can result in prolonged and severe damage to the lungs and quality of life (QoL). This study was designed to investigate the effects of 8-week Pilates and Aqua-Pilates training on pulmonary function and QoL in patients with COVID-19.
Hypothesis: Pilates and Aqua-Pilates training promotes similar changes on pulmonary function and QoL in people with a history of COVID-19.
The present study aimed to investigate the effects of combined physical training (CPT) on social skills and physical fitness (PF) in children with ASD. Sixteen children with autism (age 6-10 years) were randomly assigned into two groups: CPT and control. The CPT group participated in a program involving ball game, rhythmic movements, and resistance training for eight weeks (three sessions per week).
View Article and Find Full Text PDFExercise training increases fibronectin type III domain-containing protein 5 (FNDC5/irisin) via the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α)-pathway. The PGC1α pathway induced FNDC5/irisin changes in response to exercise training and ischemic stroke are not entirely understood. We investigated the relation of the PGC-1α/FNDC5/irisin pathway to exercise training and to the pathophysiology of ischemic stroke in paretic muscles of stroke-induced rat models.
View Article and Find Full Text PDFChronic methamphetamine use increases apoptosis, leading to heart failure and sudden cardiac death. Previous studies have shown the importance of high-intensity interval training (HIIT) in reducing indices of cardiac tissue apoptosis in different patients, but in the field of sports science, the molecular mechanisms of apoptosis in methamphetamine-dependent rats are still unclear. The present article aimed to investigate the changes in cardiac apoptosis markers in methamphetamine-dependent rats in response to HIIT.
View Article and Find Full Text PDFAdipose tissue browning is a physiological process that increases energy expenditure and may combat against obesity and its related risk factors. Fibroblast growth factor 21 (FGF21) and irisin, hormones affected by exercise that also affect adipose tissue browning, have not been widely studied with regard to exercise type and duration. This study compared the effect of high-intensity interval training (HIIT) and high-intensity resistance training (HIRT) on irisin and FGF21 in men living with overweight and obesity.
View Article and Find Full Text PDFMethamphetamine (METH) can cause neurotoxicity and increase the risk of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. This study aimed to investigate the effect of moderate-intensity interval training (MIIT) on gene expression and antioxidant status of the hippocampus of METH-dependent rats. Thirty-two male Wistar rats were randomly divided into four equal groups (n = 8): saline, METH, MIIT, and METH + MIIT.
View Article and Find Full Text PDFAt the end of 2019, a severe acute respiratory syndrome caused by SARS-CoV-2 started a pandemic, leading to millions of deaths and many important political and social changes. Even in the absence of contamination, the mobility reduction, social distancing and closing of exercise facilities negatively affected physical activity and conditioning, which is associated with muscle atrophy, loss of muscle strength, and reductions in functional capacity. In cases of infection, it has been shown that increased physical capacity is associated with decreased hospitalization and mortality risk.
View Article and Find Full Text PDFInt J Environ Res Public Health
July 2021
The aim of the present study was to analyze the effects of ballistic and power training on table tennis players' electromyography (EMG) changes. Thirty male table tennis players, who were able to perform top spin strikes properly, were randomly assigned to three groups: power training (PT; n = 10); ballistic training (BT; n = 10); and no training (CON = control group; n = 10). PT and BT were performed 3 times weekly for 8 weeks.
View Article and Find Full Text PDFHosseini Kakhak, SA, Kianigul, M, Haghighi, AH, Nooghabi, MJ, and Scott, BR. Performing soccer-specific training with blood flow restriction enhances physical capacities in youth soccer players. J Strength Cond Res 36(7): 1972-1977, 2022-This study investigated the effect of soccer training with blood flow restriction (BFR) on physical performance in youth athletes.
View Article and Find Full Text PDFAntibody-conjugated magnetic nanoparticles (Ab-MNPs) have received considerable attention in bioseparation and clinical diagnostics assays due to their unique ability to detect and isolate a variety of biomolecules and cells. Because antibodies can be expensive, a key challenge for bioconjugation is to determine the optimal amount of antibodies with reasonable antigen-capturing activity. We designed an approach to determine the minimum amounts of antibodies for efficient coating.
View Article and Find Full Text PDFHydrotalcites are quite prevalent in nature and their importance is growing more and more because of their very wide range of potential applications and uses. Because hydrotalcite does not exist in significant quantities in nature, coprecipitation methods are the most used for prepartion of hydrotalcite. In this study: Two types of Nano hydrotalcite compounds containing one divalent (Mg-Al) and two divalent cation(Co-Mg-Al) were synthesized based on aqueous solutions of corresponding nitrates by co-precipitation method.
View Article and Find Full Text PDFPurpose: The purpose of the present study was to investigate the effects of resistance and endurance training on serum adiponectin and insulin resistance index (SI) in healthy men.
Methods: Twenty-four healthy males (age, 35-48 years) participated in the study. The subjects were randomly assigned to one of three groups: endurance training group (n=8), resistance training group (n=8) and control group (n=8).