Efficacy of adding midazolam to paracetamol in pain control of patients with a primary headache: A randomized, clinical trial study.

Objectives: This study aimed to determine the effect of adding intravenous midazolam to paracetamol in the treatment of patients with primary headache referring to the emergency department.

Methods: In a randomized clinical trial, 120 patients (18-65 years old) with primary headache referring to the emergency department were enrolled. Patients were divided into two groups (case: paracetamol + midazolam and control: paracetamol + placebo), and the treatment was administered based on the treatment group.