Publications by authors named "Amir Ahmed"

Objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition influenced by various genetic and environmental factors. Currently, there is no definitive clinical test, such as a blood analysis or brain scan, for early diagnosis. The objective of this study is to develop a computational model that predicts ASD driver genes in the early stages using genomic data, aiming to enhance early diagnosis and intervention.

View Article and Find Full Text PDF

Grave's ophthalmopathy is a prevalent complication of Grave's disease. In this case report, we present a case of an 84-year-old female patient with no symptoms of hyperthyroidism except that of Grave's ophthalmopathy. The patient's thyroid profile was normal, and both thyroid receptor antibodies and thyroid-stimulating immunoglobulins were negative.

View Article and Find Full Text PDF
Article Synopsis
  • Immunotherapy, especially immune checkpoint inhibitors (ICIs), is changing cancer treatment by targeting proteins that prevent the immune system from attacking cancer cells, with key examples being PD-1, PD-L1, and CTLA-4.
  • Further research has revealed another checkpoint mechanism involving BTLA and HVEM, which are linked to immune regulation and have been found overexpressed in several cancers like lung, ovarian, and glioblastoma.
  • The exploration of the BTLA/HVEM checkpoint is important for advancing immunotherapy options, aiming to enhance cancer treatment outcomes.
View Article and Find Full Text PDF
Article Synopsis
  • In gastrointestinal stromal tumors (GISTs), identifying specific genetic mutations is crucial for predicting treatment responses and disease outcomes.
  • In a study of 95 GIST cases from the Kuwait Cancer Center, a significant majority (88%) had mutations, with most occurring in the gene, highlighting the need for targeted treatments.
  • Wild-type GISTs (without mutations) appeared to be smaller and less aggressive, but their impact on disease progression was minimal, underscoring the importance of further regional studies to connect genetics with patient outcomes.
View Article and Find Full Text PDF

Pulmonary toxicity is a serious side effect of some specific anticancer drugs. Bleomycin is a well-known anticancer drug that triggers severe reactions in the lungs. It is an approved drug that may be prescribed for the treatment of testicular cancers, Hodgkin's and non-Hodgkin's lymphomas, ovarian cancer, head and neck cancers, and cervical cancer.

View Article and Find Full Text PDF

Transition of global energy market towards an environment-friendly sustainable society requires a profound transformation from fossil fuel to zero carbon emission fuel. To cope with this goal production ofrenewable energy is accelerating worldwide. Research in renewable energy from production and storage to practical utilization requires an organized approach.

View Article and Find Full Text PDF

N6-methyladenosine (6 mA) is the most common internal modification in eukaryotic mRNA. Mass spectrometry and site-directed mutagenesis, two of the most common conventional approaches, have been shown to be laborious and challenging. In recent years, there has been a rising interest in analyzing RNA sequences to systematically investigate mutated locations.

View Article and Find Full Text PDF

Recently, nanoscience, especially metal-organic frameworks (MOFs), has been used to increase the effectiveness and properties of drugs. In this study, by using microwave irradiation; penicillin, which is a known antibiotic; and copper metal-organic frameworks (Cu-MOFs), a new penicillinoate@copper metal-organic framework (penicillinoate@Cu-MOF) was synthesized. The structure and characterization of the newly synthesized compound were determined using FT-IR spectrums, EDAX analysis, elemental analysis, XRD patterns, SEM images, nitrogen adsorption/desorption curves, and TGA curve.

View Article and Find Full Text PDF

Aims: Mitogen-activated protein kinase (MAPK) pathway alteration is a major oncogenic driver in paediatric low-grade gliomas (LGG) and some adult gliomas, encompassing BRAF (most common) and non-BRAF alterations. The aim was to determine the frequency, molecular spectrum and clinicopathological features of MAPK-altered gliomas in paediatric and adult patients at our neuropathology site in Kuwait.

Methods: We retrospectively searched the data of molecularly sequenced gliomas between 2018 and 2023 for MAPK alterations, revised the pathology in view of the 2021 WHO classification and evaluated the clinicopathological data for possible correlations.

View Article and Find Full Text PDF

Hydrogen heralded as a promising renewable and environmentally friendly energy carrier, carries inherent risks owing to its highly flammable nature. A mere 4 % concentration of hydrogen in the air can trigger an explosion. To counteract this peril, a composite material comprising PbO-ZnO (2 : 1) was synthesized, characterized, and subsequently employed to fabricate a hydrogen sensing device.

View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on a composite made from commercially pure magnesium reinforced with NbCTx MXene using a blend-press-sinter technique.
  • The NbCTx MXene was found to be well-dispersed among magnesium particles, creating stable and strong bonding without defects.
  • This reinforcement improved the mechanical properties of the magnesium, including hardness, compressive yield strength, ductility, and fracture toughness.
View Article and Find Full Text PDF

Introduction: Bilateral risk-reducing mastectomy (BRRM) involves removal of healthy breast tissue to substantially decrease the risk of developing breast cancer in individuals with greater susceptibility due to a strong family history or genetic mutation. This retrospective study evaluates cases of BRRM and associated reconstruction performed at a tertiary centre, with emphasis on mastectomy and reconstructive trends.

Methods: A retrospective review of all BRRM cases performed between January 2010 and May 2022 was conducted, with two separate cohorts corresponding to the earlier (group 1) and later (group 2) portion of the time-period.

View Article and Find Full Text PDF

Cellular vehicle-to-everything (C-V2X) is one of the enabling vehicular communication technologies gaining momentum from the standardization bodies, industry, and researchers aiming to realize fully autonomous driving and intelligent transportation systems. The 3rd Generation Partnership Project (3GPP) standardization body has actively been developing the standards evolving from 4G-V2X to 5G-V2X providing ultra-reliable low-latency communications and higher throughput to deliver the solutions for advanced C-V2X services. In this survey, we analyze the 3GPP standard documents relevant to V2X communication to present the complete vision of 3GPP-enabled C-V2X.

View Article and Find Full Text PDF

Photoactive polymer and quantum dots (QDs)/nanocrystals (NCs)-based bulk heterojunction (BHJ) solar cells have the combined positivity of organic semiconductors and inorganic components, which can enable a high carrier mobility and absorption coefficient. Additionally, the NCs also provide the opportunity to tune the band gap to obtain enhanced absorption in a broad solar spectrum. Among the semiconductors, lead chalcogenide NCs are of particular interest due to their good photosensitivity in the near-infrared (NIR) region of the solar spectrum.

View Article and Find Full Text PDF

Objective: The aim: To find out the frequency of WU and KI polyomaviruses, and Human Boca and Adenoviruses infections among children with different types of acute upper respiratory tract infections and to compare the frequency of these viruses among immune-competent and immune compromised patients.

Patients And Methods: Materials and methods: A case-control study conducted in children aged 3-18 years with acute upper respiratory tract infections. The samples were taken from: Group 1: 100 immuno competent children with acute upper respiratory tract infections.

View Article and Find Full Text PDF

High-grade calcium aluminate cement (CAC) has been successfully synthesized from municipal alumina waste and limestone under mild reaction conditions. Mineralogical composition and microstructure of the sintered mixes were investigated using X-ray diffraction and FESEM; valuable cementing phases such as CA, CA, and CA were observed in addition to the CA phase that was detected in the mixes with high CaCO content. Mix CA60 containing 60 wt% alumina waste has achieved the best sinterability (less than 1 vol% porosity) and the highest densification (~ 2.

View Article and Find Full Text PDF

The presence of lead compounds in the environment is an issue. In particular, supply water consumption has been reported to be a significant source of human exposure to lead compounds, which can pose an elevated risk to humans. Due to its toxicity, the International Agency for Research on Cancer and the US Environmental Protection Agency (USEPA) have classified lead (Pb) and its compounds as probable human carcinogens.

View Article and Find Full Text PDF

Transition metal dichalcogenides (TMDCs)-based laminar membranes have gained significant interest in energy storage, fuel cell, gas separation, wastewater treatment, and desalination applications due to single layer structure, good functionality, high mechanical strength, and chemical resistivity. Herein, we review the recent efforts and development on TMDCs-based laminar membranes, and focus is given on their fabrication strategies. Further, TMDCs-based laminar membranes for water purification and seawater desalination are discussed in detail.

View Article and Find Full Text PDF

A solid polymer, poly[(sodium methacrylate)-co-2-(methacryloyloxy)ethyl acetoacetate], p(MAA-co-MEAA) was synthesized and then grafted onto carbon nanotubes to prepare poly(MAA-co-MEAA)-grafted carbon nanotubes [CNT-g-p(MAA-co-MEAA)]. NMR, TGA, and FT-IR characterized the synthesized polymers and adsorbents. SEM-EDX was used to investigate the surface characteristics of the adsorbents.

View Article and Find Full Text PDF

Lung cancer is the leading cause of cancer mortality in the USA. In the rural Black Belt region of Alabama, high rates of lung cancer incidence and mortality coupled with disproportionate lack of access to health services stresses the need for navigating high risk and disproportionately affected groups towards successfully obtaining lung cancer screenings. We utilized our well-accepted Community Health Advisor (CHA) model for education and awareness.

View Article and Find Full Text PDF

The perovskites solar cells (PSCs) is composed of multifaceted device architecture and involve complex charge extraction (both electronic and ionic), this makes the task demanding to unlock the origin of the different physical process that occurs in a PSC. The capacitance in PSCs depends on several external perturbations including frequency, illumination, temperature, applied bias, and importantly on the interface modification of perovskites/charge selective contact. Arguably, different features including interfacial and bulk; ionic, and electronic charge transport in PSCs occur at different time scales.

View Article and Find Full Text PDF

This work presents the design and analysis of newly developed reconfigurable, flexible, inexpensive, optically-controlled, and fully printable chipless Arabic alphabet-based radio frequency identification (RFID) tags. The etching of the metallic copper tag strip is performed on a flexible simple thin paper substrate ( = 2.31) backed by a metallic ground plane.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionge3jlqelcqkbukm06apg9aobbefagb3a): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once