HIV-associated nephropathy: Protocol and rationale for an exploratory genotype-phenotype study in a sub-Saharan African population.

Background: HIV-positive persons of African descent are disproportionately affected by chronic kidney disease (CKD). Deterioration to end-stage kidney disease (ESKD) also occurs in this population at a higher frequency. There remains a lot to learn about the genetic susceptibility to CKD in HIV positive patients, and the pathophysiology of progression to ESKD.

Leiomyoma of the thyroid gland with psammoma bodies.

We report a rare case of leiomyoma of the thyroid gland associated with psammoma bodies. The patient was a 9-year-old black African boy. Prior to this, only five cases of primary thyroid leiomyoma have been reported.

Disseminated vitiligo developing around Kaposi sarcoma nodules in an AIDS patient.

Vitiligo and other autoimmune disorders are increasingly being reported in a background of immunosuppression. Viral-induced immune activation and molecular mimicry are the proposed mechanisms for the development of autoimmune diseases in individuals infected with human immunodeficiency virus (HIV). An association of vitiligo with Kaposi sarcoma (KS) rarely has been reported.

Xanthoma disseminatum in a black African woman.

Purpose: To report a partial steroid response of xanthoma disseminatum in a black African woman.

Design: Case report and literature review.

Methods: Histopathologic study of cutaneous tumour and clinical follow-up.

A multinational injury surveillance system pilot project in Africa.

This paper describes the development of a pilot project to test the implementation of an epidemiological surveillance system for intentional (violent) and non-intentional injuries, at emergency departments in selected hospitals in five African countries applying the World Health Organization's guidelines. We outline obstacles and opportunities encountered during the process. By definition, a surveillance system systematically collects, reviews, and evaluates information to understand the context in which specific injuries occur.

Gun violence in Nigeria: a focus on ethno-religious conflict in Kano.

We investigated small arms and light weapons (SALW) in Africa by reviewing the situation in Nigeria and conducting a small study in one hospital in the country's north. Published reports about SALW in Nigeria suggest that several social, economic, and political factors have caused a marked increase in gun-related violence, including ethno-religious tensions, the response of security forces to criminal activity, and growing economic disparity. In Kano, a northern city that has been the focal point of communal riots between Christians and Muslims, we found that firearm injuries were linked to these riots.

Prognostic factors in typhoid ileal perforation: a prospective study of 53 cases.

Background: Typhoid ileal perforation remains a serious complication of typhoid enteritis with high morbidity and mortality in many tropical countries.

Aims And Objectives: To determine the prognostic factors in typhoid perforation in Kano, Nigeria.

Methodology: Fifty-three consecutive patients with typhoid perforation managed surgically were prospectively studied at the general surgical unit of Aminu Kano Teaching Hospital Kano, from March 2004 to February 2006.

The triad-iodine deficiency, hyperlipidaemia, high coronary risk- in a 'maternal-neonate' population of rural Africa.

In order to see the pattern of changes in differential serum lipid and lipoprotein fractions as a risk marker of coronary complication in paired 'maternal-neonate' blood samples in an iodine deficient zone, 26 pregnant women and their corresponding new born infants at term delivery from the iodine deficient Bassa region of Plateau state, Nigeria were assessed and the results were compared with those seen in a similar 44 group of women and their newborns assessed in non lodine deficient region of Jos. The serum thyroid function and lipid and lipoprotein profiles were determined by 'ELISA' and 'enzymatic' methods respectively. Urinary iodide excretion level was also measured in 14 pregnant women in Bassa, 23 pregnant women in Jos and 16 non pregnant control from Jos.

Surgical pathology of schistosomiasis.

Schistosomiasis remains an important health problem in many tropical countries and is being seen with increasing frequency in immigrant populations and tourists in developed countries. The pattern of organ involvement and clinical presentation of schistosomiasis in 80 patients (male: female, 9:1) during a five-year period (2001-2005) was examined from archival histopathology records. The urinary bladder was the most common organ affected [50 (62.

AIDS mortality in a tertiary health institution: A four-year review.

Africa contains 70% of adults and 80% of children living with AIDS in the world and has buried 75% of the 21.8 million worldwide who have died of AIDS since the epidemic began. Nigeria, the most populous country in Africa, has 5.

Impact of iodine deficiency on thyroid function in pregnant African women - A possible factor in the genesis of 'small for dates' babies.

The effect of iodine deficiency (ID) on thyroid function in African women during pregnancy and postnatal period was examined, for which very limited information is available. Serum T(4), T(3), TSH, TBG, thyroxine binding capacity (TBK), free thyroxine index (FT(4)I=T(4)/TBK) and T(4)/TBG were determined by ELISA technique in 32 pregnant women (resident of Plateau state, Nigeria- an ID zone) through pregnancy upto term delivery, and in 5 women up to 6 weeks post delivery. Urinary iodide level was measured at delivery to determine the degree of iodine deficiency.