The contribution of limited-resource countries to the American Society of Clinical Oncology annual meetings.

Background: Limited-resource countries (LRCs) are underrepresented in biomedical research, and data with respect to oncology are lacking. The aim of the present study was to assess the participation of LRCs in the American Society of Clinical Oncology (ASCO) annual meetings.

Methods: We analyzed the characteristics of abstracts originating from LRCs presented at the 2005-2007 ASCO meetings.

Epstein-Barr virus-targeted immunotherapy for nasopharyngeal carcinoma.

Epstein-Barr virus (EBV) is constantly present in undifferentiated and poorly-differentiated nasopharyngeal cancer. Thus, tumour-associated viral antigens are potential targets for immunotherapy. Recently, both preclinical and early clinical studies have shown that various strategies can enhance EBV-specific immunity.

[Cyclooxygenase 2 inhibitors and cancer chemoprevention].

Chemoprevention is the use of natural or synthetic compounds in order to reverse, suppress or prevent the carcinogenic process. Among the many pathways dysregulated during the carcinogenic process, cyclooxygenase-2 (Cox2) seems to be one of the most promising pathways to target in order to achieve chemopreventive and anticancer effects. Indeed, Cox2 overexpression contributes to the carcinogenic by at least 5 different mechanisms including transformation of procarcinogens on carcinogens, pro-inflammatory and immunomodulatory effect, resistance to apoptosis, angiogenesis and invasion progression.

[Cyclooxygenase 2 inhibitors and cancer chemoprevention].

Chemoprevention is the use of natural or synthetic compounds in order to reverse. suppress or prevent the carcinogenic process. Among the many pathways dysregulated during the carcinogenic process, cyclooxygenase-2 (Cox2) seems to be one of the most promising pathways to target in order to achieve chemopreventive and anticancer effects.

[Epidermal growth factor receptor and chemoprevention of epithelial tumor: rationale and development methods].

Among the many pathways dysregulated during the carcinogenic process, REGF seems to be one of the most promising pathways to target in order to achieve chemopreventive and anticancer effects. Indeed, chemoprevention, the use of natural or synthetic compounds in order to reverse, suppress or prevent the carcinogenic process, aims at the cellular level at regulating the growth and sensitivity to apoptosis of premalignant and malignant clones. REGF activation leads to uncontrolled cellular proliferation, resistance to apoptosis, angiogenesis and invasion.

[Overview of epidermal growth factor inhibitors (with the exclusion of ZD1839 and C225)].

The road of EGFR is an important road of initiation and progression disease. These receptors are highly expressed in the majority of tumours and this expression is associated with a poor prognostic, more aggressiveness, a poor response to treatment, and poor survival. Inhibition of EGFR is an interesting therapeutic approach.

Breast metastasis from lung adenocarcinoma: a case report.

We report the case of a 54-year-old female patient with a stage IV lung adenocarcinoma who developed a breast mass during the course of her disease. The breast tumor was proved to be of pulmonary origin. Mammary metastases from non-small cell lung cancer are extremely rare and accurate diagnosis is essential to rule out primary breast carcinoma.