L. seed oil alleviates Bleomycin-induced pulmonary fibrosis and oxidative stress in rats.

Objective: Idiopathic pulmonary fibrosis (IPF) is the most serious form of interstitial lung disease. We aimed to investigate the effect of seed oil (DSO) on a murine model of IPF induced by bleomycin (BLM).

Methods: Male Wistar rats were treated with a single intra-tracheal injection of BLM (4 mg/kg) and a daily intraperitoneal injection of DSO (75, 150 and 300 mg/kg) for 4 weeks.