Publications by authors named "Amina Tran"
Early diagnosis remains a major limitation of cancer outcomes with ethnicity and deprivation being determinants of inequalities that impact outcomes. Prostate cancer suffers from lower incidence rates and higher mortality rates in the most deprived versus the least deprived groups. We developed the 'Man Van' to enable high-risk male patients' from deprived communities and ethnic minorities increased access to health care to address these health inequalities.
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- - Randomised control trial data suggest that stereotactic radiosurgery (SRS) is effective for patients with up to 4 brain metastases, with non-randomised data supporting its use in up to 10.
- - There is ongoing debate regarding the effectiveness of SRS for patients with more than 10 brain metastases, which this study addresses by analyzing data from 1181 patients.
- - Results indicate that median survival for patients with more than 10 brain metastases is similar to those with 2-4 metastases, suggesting these patients may also benefit from SRS treatment.
Mismatch repair-deficient (MMRd) colorectal cancers (CRCs) have high mutation burdens, which make these tumours immunogenic and many respond to immune checkpoint inhibitors. The MMRd hypermutator phenotype may also promote intratumour heterogeneity (ITH) and cancer evolution. We applied multiregion sequencing and CD8 and programmed death ligand 1 (PD-L1) immunostaining to systematically investigate ITH and how genetic and immune landscapes coevolve.
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