Publications by authors named "Amina Sabir"
Comparison of surface-enhanced Raman spectral data sets of filtrate portions of serum samples of hepatitis B and Hepatitis C infected patients obtained by centrifugal filtration.
Photodiagnosis Photodyn Ther
June 2023
Article Synopsis
- The study uses surface-enhanced Raman spectroscopy (SERS) to analyze serum samples from patients with Hepatitis B (HBV) and Hepatitis C (HCV) to improve disease diagnosis.
- By centrifugally filtering the serum samples, researchers aimed to focus on smaller biomarkers, as larger proteins could interfere with the SERS spectrum, while statistical methods like principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) further validated their findings.
- Results indicated that specific biomarkers were identified in HBV and HCV samples, differentiating them from healthy controls, which suggests SERS could be a valuable tool for diagnosing these viral infections.
Background: Sinusitis is defined as inflammation of the paranasal sinus mucous membrane lining caused by bacteria which usually invade the sinus by upper respiratory tract viral infections (UTI).
Objectives: In the present study, Surface-enhanced Raman spectroscopy (SERS) has been applied to differentiate and characterize supernatant samples, in triplicate, of three different types of bacteria which are considered leading cause of sinusitis disease.
Methods: For this purpose, supernatant samples of three different strains of bacteria namely Staphylococcus aureus, Klebsiella pneumoniae and Enterococcus faecalis.
Background: Surface Enhanced Raman Spectroscopy (SERS) is a very promising and fast technique for studying drugs and for detecting chemical nature of a molecule and DNA interaction. In the current study, SERS is employed to check the interaction of different concentrations of n-propyl imidazole derivative ligand with salmon sperm DNA using silver nanoparticles as SERS substrates.
Objectives: Multivariate data analysis technique like principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) are employed for the detailed analysis of the SERS spectral features associated with the mode of action of the imidazole derivative ligand with DNA.
Surface-enhanced Raman spectral characterization of antifungal activity of selenium and zinc based organometallic compounds.
Spectrochim Acta A Mol Biomol Spectrosc
January 2023
Surface-enhanced Raman spectroscopy (SERS) is used to identify the biochemical changes associated with the antifungal activities of selenium and zinc organometallic complexes against Aspergillus niger fungus. These biochemical changes identified in the form of SERS peaks can help to understand the mechanism of action of these antifungal agents which is important for development of new antifungal drugs. The SERS spectral changes indicate the denaturation and conformational changes of proteins and fungal cell wall decomposition in complex exposed fungal samples.
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