This study aimed to examine whether or not aluminum chloride (AlCl)-induced hepatotoxicity might be mitigated using magnetic water (MW) in rats. This study involved 28 adult male rats randomly assigned into the following 4 groups (7 rats/group): normal control (Cnt), MW, AlCl, and Al Cl + MW. The Cnt group orally received normal saline, the MW group drank MW ad libitum for 2 months, and the AlCl and AlCl + MW groups were orally administered AlCl (40 mg/kg b.
View Article and Find Full Text PDFPhysical and chemical changes in the natural of water may affect biological organisms. In this study, we highlight the effect of magnetized-water and microwave-water on rats' liver tissues. Three groups of albino rats were separated.
View Article and Find Full Text PDFPrevious studies reported disrupted hepatic function and structure following the administration of cyclosporine A (CsA) in humans and animals. Recently, we found that avocado seeds (AvS) ameliorated CsA-induced nephrotoxicity in rats. As a continuation, herein we checked whether AvS could also attenuate CsA-induced hepatotoxicity in rats.
View Article and Find Full Text PDF<b>Background and Objective:</b> Aflatoxin formed by <i>Aspergillus</i> sp. causes acute hepatotoxicity by DNA damage, gene expression disruption and induced liver carcinoma in humans and laboratory animals. The objectives of this research were to evaluate the protective role of both clay and nano clay as adsorbents to inhibit the side effect of Aflatoxin (AF) by measures the common biological assay of aflatoxicosis in rats along with hepatic gene expression and comet assay.
View Article and Find Full Text PDFCyclosporine A's (CsA) immunosuppressive effect makes it an ideal drug for organ transplantation. However, CsA's uses are restricted due to its side effects. We investigated the effects of avocado seed (AvS) powder on CsA-induced nephrotoxicity and immunosuppression in rats.
View Article and Find Full Text PDFThe use of insects as a feasible and useful natural product resource is a novel and promising option in alternative medicine. Several components from insects and their larvae have been found to inhibit molecular pathways in different stages of cancer. This study aimed to analyze the effect of aqueous and alcoholic extracts of larvae on breast cancer MCF7 cells and investigate the underlying mechanisms.
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